In vitro antimicrobial activity of ritipenem acoxil, a new oral penem, and its therapeutic efficacy in respiratory infections

Masao Tateyama, Hiroshi Fukuhara, Jun Inadome, Michihiro Gaja, Atsushi Saito, Nobuchika Kusano, Fusako Furugen, Isamu Nakasone, Shinko Taira, Yuei Irabu, Tominori Oyakawa, Mamoru Miyagi, Izuru Gakiya

Research output: Contribution to journalArticle

Abstract

We performed a basic evaluation of ritipenem acoxil (RIPM-AC), a newly developed oral penem, and clinically studied its application in the treatment of respiratory infections, with the following results. 1) Laboratory activity The minimum inhibitory concentrations (MICs) of ritipenem (RIPM) for a total of 296 strains of 13 clinically isolated species were measured and compared with those of cefaclor (CCL), cefotiam (CTM), cefixime (CFIX), cefteram (CFTM) and amoxicillin (AMPC). The activity of RIPM against gram-positive bacteria was nearly equal to that of AMPC, and thus more active than that of other antibiotics. Against gram-negative bacteria, its activity was similar to that of the other antibiotics. 2) Clinical efficacy RIPM-AC was administered to 8 patients with respiratory infections (acute bronchitis 4, acute exacerbation of chronic bronchitis 2, pneumonia 2) at 150-400 mg t.i.d. for 6-14 days. The clinical efficacy was excellent in 1 case, good in 5 cases, fair in 1 case and was not evaluated in 1 case. Causative bacteria were Haemophilus influenzae (1) and Enterobacter cloacae (1). Both of 2 strains were eradicated. No side effects were observed in any patient. As abnormal laboratory findings, eosinophilia in 1 case and elevations of s-Cr, GOT and GPT in 1 case were observed, but they were mild and transient.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalJapanese Journal of Chemotherapy
Volume43
DOIs
Publication statusPublished - Jan 1 1995
Externally publishedYes

Keywords

  • ritipenem acoxil

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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  • Cite this

    Tateyama, M., Fukuhara, H., Inadome, J., Gaja, M., Saito, A., Kusano, N., Furugen, F., Nakasone, I., Taira, S., Irabu, Y., Oyakawa, T., Miyagi, M., & Gakiya, I. (1995). In vitro antimicrobial activity of ritipenem acoxil, a new oral penem, and its therapeutic efficacy in respiratory infections. Japanese Journal of Chemotherapy, 43, 193-199. https://doi.org/10.11250/chemotherapy1995.43.Supplement3_193