In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

Khurshida Begum, Hye Sook Kim, Veena Kumar, Igor Stojiljkovic, Yusuke Wataya

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Abstract

The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalParasitology Research
Volume90
Issue number3
DOIs
Publication statusPublished - Jun 1 2003

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ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

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