In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

Khurshida Begum, Hye-Sook Kim, Veena Kumar, Igor Stojiljkovic, Yusuke Wataya

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalParasitology Research
Volume90
Issue number3
Publication statusPublished - Jun 1 2003

Fingerprint

Metalloporphyrins
protoporphyrin
Gallium
antimalarials
Antimalarials
Plasmodium falciparum
gallium
Polymerization
Inhibitory Concentration 50
Hematoporphyrins
polymerization
Trophozoites
inhibitory concentration 50
Chloroquine
Palladium
Heme
Silver
palladium
In Vitro Techniques
artemisinin

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Insect Science
  • veterinary(all)

Cite this

Begum, K., Kim, H-S., Kumar, V., Stojiljkovic, I., & Wataya, Y. (2003). In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum. Parasitology Research, 90(3), 221-224.

In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum. / Begum, Khurshida; Kim, Hye-Sook; Kumar, Veena; Stojiljkovic, Igor; Wataya, Yusuke.

In: Parasitology Research, Vol. 90, No. 3, 01.06.2003, p. 221-224.

Research output: Contribution to journalArticle

Begum, K, Kim, H-S, Kumar, V, Stojiljkovic, I & Wataya, Y 2003, 'In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum', Parasitology Research, vol. 90, no. 3, pp. 221-224.
Begum, Khurshida ; Kim, Hye-Sook ; Kumar, Veena ; Stojiljkovic, Igor ; Wataya, Yusuke. / In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum. In: Parasitology Research. 2003 ; Vol. 90, No. 3. pp. 221-224.
@article{e394212a8adc43389579a3ccc91afd5e,
title = "In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum",
abstract = "The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50{\%} inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.",
author = "Khurshida Begum and Hye-Sook Kim and Veena Kumar and Igor Stojiljkovic and Yusuke Wataya",
year = "2003",
month = "6",
day = "1",
language = "English",
volume = "90",
pages = "221--224",
journal = "Parasitology Research",
issn = "0932-0113",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - In vitro antimalarial activity of metalloporphyrins against Plasmodium falciparum

AU - Begum, Khurshida

AU - Kim, Hye-Sook

AU - Kumar, Veena

AU - Stojiljkovic, Igor

AU - Wataya, Yusuke

PY - 2003/6/1

Y1 - 2003/6/1

N2 - The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

AB - The in vitro antimalarial activity against Plasmodium falciparum and heine polymerization were evaluated for ten metalloporphyrins: gallium protoporphyrin IX (GaPPIX), sodium salt of gallium protoporphyrin IX, silver protoporphyrin IX, palladium protoporphyrin IX, cobalt protoporphyrin IX, manganese protoporphyrin IX, tin protoporphyrin IX (SnPPIX), chromium protoporphyrin IX, gallium deuteroporphyrin IX (GaDPIX) and gallium hematoporphyrin IX. Metalloporphyrins inhibited parasite growth with 50% inhibitory concentrations (IC50) ranging from 15.5 μM to 190 μM. In trophozoite lysate-mediated heme polymerization assays, SnPPIX, GaPPIX and GaDPIX exerted potent inhibitory activity similar to that of artemisinin and chloroquine.

UR - http://www.scopus.com/inward/record.url?scp=0038686310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038686310&partnerID=8YFLogxK

M3 - Article

VL - 90

SP - 221

EP - 224

JO - Parasitology Research

JF - Parasitology Research

SN - 0932-0113

IS - 3

ER -