In vitro antibacterial activity of meropenem, a new carbapenem antibiotic

Yoshihiro Sumita, Susumu Mitsuhashi, Matsuhisa Inoue, Matsuhisa Inoue

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The in vitro activity of the new carbapenem, meropenem (MEPM) was tested in comparison with imipenem (IPM), ceftazidime, cefotaxime, latamoxef and flomoxef. MEPM showed good activity against a broad spectrum of gram-positive and gram-negative standard bacteria, including Pseudomonas aeruginosa. The activity of MEPM against gram-positive cocci was about one-fourth that of IPM. MEPM was highly active against gram-negative bacteria, inhibiting all Enterobacteriaceae, except for 25% of Serratia marcescens isolates, at a concentration of 0.78 µg/ml. MEPM also showed a high activity against P. aeruginosa, its activity being two-fold higher than that of IPM. Against anaerobes, MEPM also had the best activity of the β-lactams tested. The compound was inactive against methicillin-resistant staphylococci, Enterococcus faecium, Xanthomonas maltophilia and Flavobacterium spp., as were the other β-lactams. MEPM also showed bactericidal activity against clinical isolates of methicillin-susceptible Staphylococcus aureus, Escherichia coli, Proteus vulgaris and P. aeruginosa at the MIC or at concentrations slightly above the MIC. MEPM was quite stable against various types of β-lactamase, but was hydrolyzed by X. maltophilia L-1 type β-lactamase, as were IPM and other β-lactams. This high degree of stability was responsible for the potent activity of MEPM against β-lactamase-producing species such as Enterobacter cloacae, Citrobacter freundii and P. vulgaris.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalCHEMOTHERAPY
Volume40
DOIs
Publication statusPublished - Jan 1 1992

Keywords

  • Meropenem
  • β-lactamase

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Infectious Diseases
  • Pharmacology
  • Drug Discovery
  • Oncology

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