In situ monitoring of drug action using sensors

Takashi Katsu, Keiko Komagoe, Kazufumi Masuda, Hisato Kato, Tsuyoshi Inoue

Research output: Contribution to journalArticle

Abstract

The application of electrochemical sensors to biochemical analysis is attractive, because the measurement is fast, easy, and continuous in a turbid cell suspension. In addition, the apparatus used is inexpensive. In this paper, we report on how electrochemical sensors, such as oxygen electrode and ion sensors, are useful to analyze the photoinactivation of bacteria induced by dyes. Furthermore, we coupled a K+ sensor with spectrometry. This methodology enabled us to rapidly screen the sizes of pores formed in a liposomal membrane. We also describe a simple method for constructing ion sensors in a laboratory.

Original languageEnglish
Pages (from-to)121-130
Number of pages10
JournalBUNSEKI KAGAKU
Volume62
Issue number2
DOIs
Publication statusPublished - 2013

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Keywords

  • In situ monitoring
  • Ion sensor
  • Membrane-active drug
  • Oxygen electrode
  • Photoinactivation

ASJC Scopus subject areas

  • Analytical Chemistry

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