In situ monitoring of drug action using sensors

Takashi Katsu; Keiko Komagoe; Kazufumi Masuda; Hisato Kato; Tsuyoshi Inoue

doi:10.2116/bunsekikagaku.62.121

In situ monitoring of drug action using sensors

Takashi Katsu, Keiko Komagoe, Kazufumi Masuda, Hisato Kato, Tsuyoshi Inoue

Research output: Contribution to journal › Article

Abstract

The application of electrochemical sensors to biochemical analysis is attractive, because the measurement is fast, easy, and continuous in a turbid cell suspension. In addition, the apparatus used is inexpensive. In this paper, we report on how electrochemical sensors, such as oxygen electrode and ion sensors, are useful to analyze the photoinactivation of bacteria induced by dyes. Furthermore, we coupled a K⁺ sensor with spectrometry. This methodology enabled us to rapidly screen the sizes of pores formed in a liposomal membrane. We also describe a simple method for constructing ion sensors in a laboratory.

Original language	English
Pages (from-to)	121-130
Number of pages	10
Journal	BUNSEKI KAGAKU
Volume	62
Issue number	2
DOIs	https://doi.org/10.2116/bunsekikagaku.62.121
Publication status	Published - 2013

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Keywords

In situ monitoring
Ion sensor
Membrane-active drug
Oxygen electrode
Photoinactivation

ASJC Scopus subject areas

Analytical Chemistry

Cite this

Katsu, T., Komagoe, K., Masuda, K., Kato, H., & Inoue, T. (2013). In situ monitoring of drug action using sensors. BUNSEKI KAGAKU, 62(2), 121-130. https://doi.org/10.2116/bunsekikagaku.62.121

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10.2116/bunsekikagaku.62.121