In-line filter occlusion during intravenous delivery of injectable menatetrenone (vitamin K2)

T. Sendo, K. Adachi, K. Otsubo, T. Aoyama, R. Oishi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Filter occlusion during intravenous infusion of injectable menatetrenone in an electrolyte fluid was examined. The menatetrenone concentration and its emulsion droplet size were not changed by in-line filtration. However, particle counts in the admixed solution and examination of scanning electron micrographs of the surface of the filter membrane indicated that particle formation occurred immediately after the admixture of menatetrenone injection with Hicaliq No. 2, but not with 5% glucose injection. This may be due to the interaction of excess lecithin in the emulsion with the electrolyte. Filter occlusion also occurred with the admixture of menatetrenone-free emulsion and Hicaliq No. 2, but not with 5% glucose injection. These findings indicate that injectable menatetrenone should not be admixed with electrolyte fluids.

Original languageEnglish
Pages (from-to)9-13
Number of pages5
JournalJournal of Clinical Pharmacy and Therapeutics
Volume21
Issue number1
DOIs
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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