Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: Effect of introduction of fluorine at the linker part

Jun ichi Kasuga, Takuji Oyama, Yuko Hirakawa, Makoto Makishima, Kosuke Morikawa, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylpropionic acid-type pan agonist TIPP-703.

Original languageEnglish
Pages (from-to)4525-4528
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number16
DOIs
Publication statusPublished - Aug 15 2008

Keywords

  • Fluorine
  • PPAR
  • PPAR pan agonist

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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