Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists

Effect of introduction of fluorine at the linker part

Jun ichi Kasuga, Takuji Oyama, Yuko Hirakawa, Makoto Makishima, Kosuke Morikawa, Yuichi Hashimoto, Hiroyuki Miyachi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We developed a potent peroxisome proliferator-activated receptor pan agonist (a candidate drug for treatment of altered metabolic homeostasis) by introducing fluorine atoms at appropriate position(s) of the known phenylpropionic acid-type pan agonist TIPP-703.

Original languageEnglish
Pages (from-to)4525-4528
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number16
DOIs
Publication statusPublished - Aug 15 2008
Externally publishedYes

Fingerprint

Peroxisome Proliferator-Activated Receptors
Fluorine
Transcriptional Activation
Homeostasis
Atoms
Acids
Pharmaceutical Preparations
TIPP 703

Keywords

  • Fluorine
  • PPAR
  • PPAR pan agonist

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists : Effect of introduction of fluorine at the linker part. / Kasuga, Jun ichi; Oyama, Takuji; Hirakawa, Yuko; Makishima, Makoto; Morikawa, Kosuke; Hashimoto, Yuichi; Miyachi, Hiroyuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 16, 15.08.2008, p. 4525-4528.

Research output: Contribution to journalArticle

Kasuga, Jun ichi ; Oyama, Takuji ; Hirakawa, Yuko ; Makishima, Makoto ; Morikawa, Kosuke ; Hashimoto, Yuichi ; Miyachi, Hiroyuki. / Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists : Effect of introduction of fluorine at the linker part. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 16. pp. 4525-4528.
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