Improvement of 99mTc-pyrophosphate scintigraphy in detection of acute myocardial infarction: Combined with 99mTc-tetrofosmin

M. Kawano, J. Taki, S. Kinuya, T. Higuchi, K. Nakajima, Y. Miyazaki, Y. Murata, N. Tonami

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


[Background] 201Tl and 99mTc-pyrophosphate (PYP) dual scintigraphy is daily used in the detection of acute myocardial infarction (AMI). However, 201Tl is not available on emergent situation. We proposed a new method for detection of AMI combined 99mTc-PYP with 99mTc-tetrofosmin (TF). [Methods] 99mTc-PYP (740 MBq) was administered to 25 patients with AMI, and 3.5 hours later, planar imaging (PYP planar) and SPECT were performed (PYP-SPECT). Immediately after cessation of PYP-SPECT, 99mTc-TF (370-740 MBq) was injected and 5 minutes later SPECT was performed in the same position (TF-SPECT). PYP-SPECT and TF-SPECT were reconstructed in the same geometric status to permit superimpose of PYP-SPECT and TF-SPECT images. Two experts and 2 beginners of nuclear medicine physician interpreted the images in three ways; PYP planar image only, PYP-SPECT, and PYP-SPECT with TF-SPECT. [Results] PYP-SPECT combined with TF-SPECT shows 100% detectability of the AMI lesions, which is significantly higher than other two methods in both experts and beginners. [Conclusion] PYP-SPECT combined with TF-SPECT is a powerful method for detection of AMI.

Original languageEnglish
Pages (from-to)707-713
Number of pages7
Issue number6
Publication statusPublished - 2001
Externally publishedYes


  • Acute myocardial infarction
  • Detectability
  • Tc-pyrophosphate
  • Tc-tetrofosmin

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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