TY - JOUR
T1 - Improvement of 99mTc-pyrophosphate scintigraphy in detection of acute myocardial infarction
T2 - Combined with 99mTc-tetrofosmin
AU - Kawano, M.
AU - Taki, J.
AU - Kinuya, S.
AU - Higuchi, T.
AU - Nakajima, K.
AU - Miyazaki, Y.
AU - Murata, Y.
AU - Tonami, N.
PY - 2001
Y1 - 2001
N2 - [Background] 201Tl and 99mTc-pyrophosphate (PYP) dual scintigraphy is daily used in the detection of acute myocardial infarction (AMI). However, 201Tl is not available on emergent situation. We proposed a new method for detection of AMI combined 99mTc-PYP with 99mTc-tetrofosmin (TF). [Methods] 99mTc-PYP (740 MBq) was administered to 25 patients with AMI, and 3.5 hours later, planar imaging (PYP planar) and SPECT were performed (PYP-SPECT). Immediately after cessation of PYP-SPECT, 99mTc-TF (370-740 MBq) was injected and 5 minutes later SPECT was performed in the same position (TF-SPECT). PYP-SPECT and TF-SPECT were reconstructed in the same geometric status to permit superimpose of PYP-SPECT and TF-SPECT images. Two experts and 2 beginners of nuclear medicine physician interpreted the images in three ways; PYP planar image only, PYP-SPECT, and PYP-SPECT with TF-SPECT. [Results] PYP-SPECT combined with TF-SPECT shows 100% detectability of the AMI lesions, which is significantly higher than other two methods in both experts and beginners. [Conclusion] PYP-SPECT combined with TF-SPECT is a powerful method for detection of AMI.
AB - [Background] 201Tl and 99mTc-pyrophosphate (PYP) dual scintigraphy is daily used in the detection of acute myocardial infarction (AMI). However, 201Tl is not available on emergent situation. We proposed a new method for detection of AMI combined 99mTc-PYP with 99mTc-tetrofosmin (TF). [Methods] 99mTc-PYP (740 MBq) was administered to 25 patients with AMI, and 3.5 hours later, planar imaging (PYP planar) and SPECT were performed (PYP-SPECT). Immediately after cessation of PYP-SPECT, 99mTc-TF (370-740 MBq) was injected and 5 minutes later SPECT was performed in the same position (TF-SPECT). PYP-SPECT and TF-SPECT were reconstructed in the same geometric status to permit superimpose of PYP-SPECT and TF-SPECT images. Two experts and 2 beginners of nuclear medicine physician interpreted the images in three ways; PYP planar image only, PYP-SPECT, and PYP-SPECT with TF-SPECT. [Results] PYP-SPECT combined with TF-SPECT shows 100% detectability of the AMI lesions, which is significantly higher than other two methods in both experts and beginners. [Conclusion] PYP-SPECT combined with TF-SPECT is a powerful method for detection of AMI.
KW - Acute myocardial infarction
KW - Detectability
KW - SPECT
KW - Tc-pyrophosphate
KW - Tc-tetrofosmin
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M3 - Article
C2 - 11806081
AN - SCOPUS:0035543985
VL - 38
SP - 707
EP - 713
JO - Kaku igaku. The Japanese journal of nuclear medicine
JF - Kaku igaku. The Japanese journal of nuclear medicine
SN - 0022-7854
IS - 6
ER -