Improved syntheses of d-ribo- and 2-deoxy-d-ribofuranose phospho sugars from methyl β-d-ribopyranoside

Tadashi Hanaya, Yuko Koga, Heizan Kawamoto, Hiroshi Yamamoto

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Abstract - Methyl 4-deoxy-4-dimethoxyphosphinoyl-2,3-O-isopropylidene-13-D-ribopyranoside (12a) and methyl 2,4-dideoxy-4-dimethoxyphosphinoyl-13-D-etythro-pentopyranoside (20) were efficiently prepared respectively from methyl2,3-O-isopropylidene-[3-D-ribopyranoside (7a) and its 3,4-O-isopropylideneisomer (7b) in appreciably improved total yields compared with those via previously reported routes.Compounds (12a, 20) were led to D-ribofuranos and 2-deoxy-D-ribofuranose phospho sugars (4, 5).

Original languageEnglish
Pages (from-to)581-591
Number of pages11
JournalHeterocycles
Volume73
Issue numberC
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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