Improved quality of life in a patient with carcinomatous meningitis from invasive lobular carcinoma treated with intrathecal MTX and Ara-C in combination with systemic docetaxel

Masatoshi Kubo, Masaru Jida, Masaomi Yamane, Katsuya Miyatani, Tetsunobu Udaka, Osanori Sogabe, Hiroya Maeda, Minoru Mizuta, Kazutoyo Shirakawa

Research output: Contribution to journalArticle

Abstract

Carcinomatous meningitis from breast cancer is rare and has a poor prognosis with a life expectancy of approximately 80 days. We performed intrathecal MTX and Ara-C in combination with systemic docetaxel treatments in the patient, a 44-year-old woman with carcinomatous meningitis from invasive lobular carcinoma previously treated with anthracycline and paclitaxel. Although the patient died 128 days after the onset, intrathecal chemotherapy in combination with systemic docetaxel reduced the number of malignant cells and induced degeneration of the cells in CSF, resulting in improved quality of life.

Original languageEnglish
Pages (from-to)2097-2099
Number of pages3
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume32
Issue number13
Publication statusPublished - Dec 2005
Externally publishedYes

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docetaxel
Meningeal Carcinomatosis
Lobular Carcinoma
Cytarabine
Quality of Life
Breast Neoplasms
Anthracyclines
Life Expectancy
Paclitaxel
Combination Drug Therapy
Cell Count
Therapeutics

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

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Improved quality of life in a patient with carcinomatous meningitis from invasive lobular carcinoma treated with intrathecal MTX and Ara-C in combination with systemic docetaxel. / Kubo, Masatoshi; Jida, Masaru; Yamane, Masaomi; Miyatani, Katsuya; Udaka, Tetsunobu; Sogabe, Osanori; Maeda, Hiroya; Mizuta, Minoru; Shirakawa, Kazutoyo.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 32, No. 13, 12.2005, p. 2097-2099.

Research output: Contribution to journalArticle

Kubo, Masatoshi ; Jida, Masaru ; Yamane, Masaomi ; Miyatani, Katsuya ; Udaka, Tetsunobu ; Sogabe, Osanori ; Maeda, Hiroya ; Mizuta, Minoru ; Shirakawa, Kazutoyo. / Improved quality of life in a patient with carcinomatous meningitis from invasive lobular carcinoma treated with intrathecal MTX and Ara-C in combination with systemic docetaxel. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2005 ; Vol. 32, No. 13. pp. 2097-2099.
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abstract = "Carcinomatous meningitis from breast cancer is rare and has a poor prognosis with a life expectancy of approximately 80 days. We performed intrathecal MTX and Ara-C in combination with systemic docetaxel treatments in the patient, a 44-year-old woman with carcinomatous meningitis from invasive lobular carcinoma previously treated with anthracycline and paclitaxel. Although the patient died 128 days after the onset, intrathecal chemotherapy in combination with systemic docetaxel reduced the number of malignant cells and induced degeneration of the cells in CSF, resulting in improved quality of life.",
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AU - Yamane, Masaomi

AU - Miyatani, Katsuya

AU - Udaka, Tetsunobu

AU - Sogabe, Osanori

AU - Maeda, Hiroya

AU - Mizuta, Minoru

AU - Shirakawa, Kazutoyo

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