Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms

Shinji Motomura, Yousuke Kanayama, Makoto Hiromura, Tomonori Fukuchi, Takahiro Ida, Hiromitsu Haba, Yasuyoshi Watanabe, Shuichi Enomoto

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.

Original languageEnglish
Pages (from-to)934-939
Number of pages6
JournalJournal of Analytical Atomic Spectrometry
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2013

Fingerprint

Metal analysis
Molecular imaging
Cameras
Semiconductor materials
Imaging techniques
Tumors
Gamma rays
Cells
Antibodies
Experiments

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

Cite this

Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms. / Motomura, Shinji; Kanayama, Yousuke; Hiromura, Makoto; Fukuchi, Tomonori; Ida, Takahiro; Haba, Hiromitsu; Watanabe, Yasuyoshi; Enomoto, Shuichi.

In: Journal of Analytical Atomic Spectrometry, Vol. 28, No. 6, 06.2013, p. 934-939.

Research output: Contribution to journalArticle

Motomura, Shinji ; Kanayama, Yousuke ; Hiromura, Makoto ; Fukuchi, Tomonori ; Ida, Takahiro ; Haba, Hiromitsu ; Watanabe, Yasuyoshi ; Enomoto, Shuichi. / Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms. In: Journal of Analytical Atomic Spectrometry. 2013 ; Vol. 28, No. 6. pp. 934-939.
@article{cba48a6dafcf42e0a834e787e8a2ee27,
title = "Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms",
abstract = "We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.",
author = "Shinji Motomura and Yousuke Kanayama and Makoto Hiromura and Tomonori Fukuchi and Takahiro Ida and Hiromitsu Haba and Yasuyoshi Watanabe and Shuichi Enomoto",
year = "2013",
month = "6",
doi = "10.1039/c3ja30185k",
language = "English",
volume = "28",
pages = "934--939",
journal = "Journal of Analytical Atomic Spectrometry",
issn = "0267-9477",
publisher = "Royal Society of Chemistry",
number = "6",

}

TY - JOUR

T1 - Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms

AU - Motomura, Shinji

AU - Kanayama, Yousuke

AU - Hiromura, Makoto

AU - Fukuchi, Tomonori

AU - Ida, Takahiro

AU - Haba, Hiromitsu

AU - Watanabe, Yasuyoshi

AU - Enomoto, Shuichi

PY - 2013/6

Y1 - 2013/6

N2 - We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.

AB - We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.

UR - http://www.scopus.com/inward/record.url?scp=84878102329&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878102329&partnerID=8YFLogxK

U2 - 10.1039/c3ja30185k

DO - 10.1039/c3ja30185k

M3 - Article

AN - SCOPUS:84878102329

VL - 28

SP - 934

EP - 939

JO - Journal of Analytical Atomic Spectrometry

JF - Journal of Analytical Atomic Spectrometry

SN - 0267-9477

IS - 6

ER -