Abstract
We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.
| Original language | English |
|---|---|
| Pages (from-to) | 934-939 |
| Number of pages | 6 |
| Journal | Journal of Analytical Atomic Spectrometry |
| Volume | 28 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2013 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Spectroscopy
Cite this
Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms. / Motomura, Shinji; Kanayama, Yousuke; Hiromura, Makoto; Fukuchi, Tomonori; Ida, Takahiro; Haba, Hiromitsu; Watanabe, Yasuyoshi; Enomoto, Shuichi.
In: Journal of Analytical Atomic Spectrometry, Vol. 28, No. 6, 06.2013, p. 934-939.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Improved imaging performance of a semiconductor Compton camera GREI makes for a new methodology to integrate bio-metal analysis and molecular imaging technology in living organisms
AU - Motomura, Shinji
AU - Kanayama, Yousuke
AU - Hiromura, Makoto
AU - Fukuchi, Tomonori
AU - Ida, Takahiro
AU - Haba, Hiromitsu
AU - Watanabe, Yasuyoshi
AU - Enomoto, Shuichi
PY - 2013/6
Y1 - 2013/6
N2 - We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.
AB - We have constructed the second prototype of the semiconductor Compton camera GREI that enables spectroscopic imaging of wide energy-range gamma-rays. The improved imaging performance has been demonstrated by an imaging experiment with a tumor-baring live mouse, where we were able to obtain the distribution images of the 64Cu-labeled antibody to the implanted three tumor sites of different cell lines, together with that of 65Zn, which was simultaneously administered as ZnCl2 solution. The imaging performance has been compared with that of the primary prototype of GREI, and the importance of the improvement for the simultaneous imaging of multiple radiotracers has been revealed. The methodology offered by GREI is expected to make a unique contribution toward establishing a new viewpoint for understanding life phenomena.
UR - http://www.scopus.com/inward/record.url?scp=84878102329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878102329&partnerID=8YFLogxK
U2 - 10.1039/c3ja30185k
DO - 10.1039/c3ja30185k
M3 - Article
AN - SCOPUS:84878102329
VL - 28
SP - 934
EP - 939
JO - Journal of Analytical Atomic Spectrometry
JF - Journal of Analytical Atomic Spectrometry
SN - 0267-9477
IS - 6
ER -