Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma

Yasuhiro Ebihara; Saori Yoshida; Mitsuhiko Nakahira; Yasunao Kogashiwa; Yuichiro Enoki; Kiyomi Kuba; Hitoshi Inoue; Kazuhiko Minami; Masanori Yasuda; Masashi Sugasawa

doi:10.1002/hed.25614

Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma

Yasuhiro Ebihara, Saori Yoshida, Mitsuhiko Nakahira, Yasunao Kogashiwa, Yuichiro Enoki, Kiyomi Kuba, Hitoshi Inoue, Kazuhiko Minami, Masanori Yasuda, Masashi Sugasawa

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P =.008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P =.02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.

Original language	English
Pages (from-to)	1809-1815
Number of pages	7
Journal	Head and Neck
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/hed.25614
Publication status	Published - Jun 2019
Externally published	Yes

Keywords

budding
early tongue cancer
lymph node metastasis
multivariate analysis
prognostic factor

ASJC Scopus subject areas

Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.25614

Cite this

@article{2b537f21fcbe4e53a9814a8459b32aa8,

title = "Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma",

abstract = "Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P =.008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P =.02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.",

keywords = "budding, early tongue cancer, lymph node metastasis, multivariate analysis, prognostic factor",

author = "Yasuhiro Ebihara and Saori Yoshida and Mitsuhiko Nakahira and Yasunao Kogashiwa and Yuichiro Enoki and Kiyomi Kuba and Hitoshi Inoue and Kazuhiko Minami and Masanori Yasuda and Masashi Sugasawa",

note = "Funding Information: The authors are grateful to Koichi Kamata for substantial contributions to technical support of immunohistochemical staining. This study was supported by a Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research C (Grant No. 17K11404). Funding Information: JSPS Grant-in-Aid for Scientific Research C, Grant/Award Number: 17K11404; Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research C, Grant/Award Number: 17K11404 Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = jun,

doi = "10.1002/hed.25614",

language = "English",

volume = "41",

pages = "1809--1815",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma

AU - Ebihara, Yasuhiro

AU - Yoshida, Saori

AU - Nakahira, Mitsuhiko

AU - Kogashiwa, Yasunao

AU - Enoki, Yuichiro

AU - Kuba, Kiyomi

AU - Inoue, Hitoshi

AU - Minami, Kazuhiko

AU - Yasuda, Masanori

AU - Sugasawa, Masashi

N1 - Funding Information: The authors are grateful to Koichi Kamata for substantial contributions to technical support of immunohistochemical staining. This study was supported by a Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research C (Grant No. 17K11404). Funding Information: JSPS Grant-in-Aid for Scientific Research C, Grant/Award Number: 17K11404; Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research C, Grant/Award Number: 17K11404 Publisher Copyright: © 2019 Wiley Periodicals, Inc.

PY - 2019/6

Y1 - 2019/6

N2 - Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P =.008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P =.02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.

AB - Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P =.008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P =.02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.

KW - budding

KW - early tongue cancer

KW - lymph node metastasis

KW - multivariate analysis

KW - prognostic factor

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JO - Head and Neck

JF - Head and Neck

IS - 6

ER -

Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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