Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma

Yasuhiro Ebihara, Saori Yoshida, Mitsuhiko Nakahira, Yasunao Kogashiwa, Yuichiro Enoki, Kiyomi Kuba, Hitoshi Inoue, Kazuhiko Minami, Masanori Yasuda, Masashi Sugasawa

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background: Factors involved in neck lymph node metastasis (NLM) and prognosis of early tongue squamous cell carcinoma (SCC) remain unknown. Methods: We analyzed disease-specific survival (DSS) and NLM including tumor budding grade (TBG) among 64 patients with cT1/2N0 tongue SCC. Results: Univariate analysis of DSS of primary lesions uncovered significant differences in new cT, pT, new pT, pDiameter, venous infiltration, and TBG. Multivariate analysis selected only TBG3 as a predictor of NLM (odds ratio, 9.55; 95% confidence interval [CI], 1.80-50.8; P =.008), and a prognostic factor for DSS (hazard ratio, 4.41; 95% CI, 1.34-14.5; P =.02). Conclusion: The sole predictor of NLM and the prognosis of early tongue SCC was TBG, indicating that it might help to select overwhelming risk patients.

Original languageEnglish
Pages (from-to)1809-1815
Number of pages7
JournalHead and Neck
Volume41
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • budding
  • early tongue cancer
  • lymph node metastasis
  • multivariate analysis
  • prognostic factor

ASJC Scopus subject areas

  • Otorhinolaryngology

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