Importance of hepatovenous back-perfusion for maintenance of liver viability during the Pringle manoeuvre

T. Tatsuma, Y. I. Kim, T. Kai, T. Ishii, S. Akizuki, Fusako Takayama, T. Egashira, M. Kobayashi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The role of hepatovenous back-perfusion in maintaining hepatic viability was investigated during inflow occlusion (Pringle manoeuvre) of the pig liver. The study compared two ischaemia procedures of 60 min duration: hepatic inflow occlusion and inflow plus outflow occlusion (vascular exclusion). Each procedure was carried out in six pigs and liver tissue perfusion, energy metabolism, lipid peroxidation and 7-day survival were assessed. Although all pigs survived after inflow occlusion, five of six died after vascular exclusion (P <0.01). Exclusion induced a significant decrease in perfusion to 15.3 per cent of the value before ischaemia compared with 32.4 per cent after hepatic inflow occlusion alone (P <0.01). Although cellular adenosine 5'-triphosphate levels were significantly decreased by ischaemia in both groups, the fall was less in pigs with inflow occlusion alone (to 55 per cent of the preclamp value) than in those with exclusion (to 24 per cent of the preclamp value) (P <0.01). The plasma phosphatidylcholine hydroperoxide level rose immediately after reperfusion in pigs with exclusion, while the level remained constant after inflow occlusion alone. There is a fundamental difference between the two ischaemia procedures: back-perfusion from the vena cava contributes to the maintenance of liver function during inflow occlusion.

Original languageEnglish
Pages (from-to)1071-1075
Number of pages5
JournalBritish Journal of Surgery
Volume82
Issue number8
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Perfusion
Maintenance
Swine
Liver
Ischemia
Blood Vessels
Venae Cavae
Energy Metabolism
Lipid Peroxidation
Reperfusion
Adenosine Triphosphate

ASJC Scopus subject areas

  • Surgery

Cite this

Importance of hepatovenous back-perfusion for maintenance of liver viability during the Pringle manoeuvre. / Tatsuma, T.; Kim, Y. I.; Kai, T.; Ishii, T.; Akizuki, S.; Takayama, Fusako; Egashira, T.; Kobayashi, M.

In: British Journal of Surgery, Vol. 82, No. 8, 1995, p. 1071-1075.

Research output: Contribution to journalArticle

Tatsuma, T. ; Kim, Y. I. ; Kai, T. ; Ishii, T. ; Akizuki, S. ; Takayama, Fusako ; Egashira, T. ; Kobayashi, M. / Importance of hepatovenous back-perfusion for maintenance of liver viability during the Pringle manoeuvre. In: British Journal of Surgery. 1995 ; Vol. 82, No. 8. pp. 1071-1075.
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