Impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with changes in the hippocampal cholinergic and noradrenergic contents

Takashi Egawa, Kenichi Mishima, Nobuaki Egashira, Misa Fukuzawa, Kohji Abe, Tetsuji Yae, Katsunori Iwasaki, Michihiro Fujiwara

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the relationship between the degree of spatial memory impairment in an 8-arm radial maze and the changes in the contents of acetylcholine (ACh) and noradrenaline (NA) in the dorsal and ventral hippocampus and the frontal cortex, along with histological changes in kaolin-induced hydrocephalic rats. Kaolin-induced hydrocephalic rats were divided into three groups (non-impaired, impaired and severely impaired) according to the degree of impairment in a radial maze. Thirty percent of the hydrocephalic rats could not solve a radial maze (severely impaired group), while the remaining hydrocephalic rats could (non-impaired rats in the standard task). Forty percent of the non-impaired rats in the standard task failed to solve the delayed-response task (impaired group), whereas the remaining rats were able to solve it (non-impaired group). A positive correlation was observed between the impairment of spatial memory and ventricular dilatation. The ACh content in the dorsal and ventral hippocampus, and the NA content in the ventral hippocampus were decreased in the severely impaired group. Moreover, the NA content in the ventral hippocampus was decreased in the impaired group. These results suggest that the impairment of spatial memory in kaolin-induced hydrocephalic rats is associated with dysfunction of the hippocampal cholinergic and noradrenergic systems.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalBehavioural Brain Research
Volume129
Issue number1-2
DOIs
Publication statusPublished - Feb 1 2002
Externally publishedYes

Keywords

  • 8-arm radial maze
  • Acetylcholine
  • HPLC-ECD
  • Kaolin
  • Noradrenaline
  • Normal-pressure hydrocephalus
  • Spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

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