Impairment of leukocyte deformability in patients undergoing esophagectomy

Tomohiko Suemori, Hiroshi Morimatsu, Satoshi Mizobuchi, Kiyoshi Morita, Yuki Katanosaka, Satoshi Mohri, Keiji Naruse

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Impaired deformability might contribute to the accumulation of activated leukocytes within pulmonary microcapillaries, leading to acute lung injury. The purpose of our study was to investigate changes in leukocyte deformability during periods of inflammation after esophagectomy. The study group comprised 20 patients who underwent esophagectomy. Changes in leukocyte deformability were investigated by examining filtration through a silicon microchannel, which simulated human pulmonary microcapillaries. Changes in the neutrophil cytoskeleton were investigated by measuring neutrophil F-actin assembly. The severity of patient clinical outcome was evaluated by the lung injury score. Leukocyte filtration through the microchannel was significantly weaker in esophagectomy patients than in healthy subjects (p

Original languageEnglish
Pages (from-to)127-136
Number of pages10
JournalClinical Hemorheology and Microcirculation
Volume41
Issue number2
DOIs
Publication statusPublished - 2009

Fingerprint

Esophagectomy
Leukocytes
Neutrophils
Lung
Acute Lung Injury
Lung Injury
Silicon
Cytoskeleton
Actins
Healthy Volunteers
Inflammation

Keywords

  • Cytoskeleton
  • Esophagectomy
  • F-actin
  • Lung injury
  • Microchannel

ASJC Scopus subject areas

  • Hematology
  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Impairment of leukocyte deformability in patients undergoing esophagectomy. / Suemori, Tomohiko; Morimatsu, Hiroshi; Mizobuchi, Satoshi; Morita, Kiyoshi; Katanosaka, Yuki; Mohri, Satoshi; Naruse, Keiji.

In: Clinical Hemorheology and Microcirculation, Vol. 41, No. 2, 2009, p. 127-136.

Research output: Contribution to journalArticle

Suemori, Tomohiko ; Morimatsu, Hiroshi ; Mizobuchi, Satoshi ; Morita, Kiyoshi ; Katanosaka, Yuki ; Mohri, Satoshi ; Naruse, Keiji. / Impairment of leukocyte deformability in patients undergoing esophagectomy. In: Clinical Hemorheology and Microcirculation. 2009 ; Vol. 41, No. 2. pp. 127-136.
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