Impaired psii proteostasis promotes retrograde signaling via salicylic acid1

Jianli Duan, Keun Pyo Lee, Vivek Dogra, Siyuan Zhang, Kaiwei Liu, Carlos Caceres-Moreno, Shanshan Lv, Weiman Xing, Yusuke Kato, Wataru Sakamoto, Renyi Liu, Alberto P. Macho, Chanhong Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Photodamage of the PSII reaction center (RC) is an inevitable process in an oxygen-rich environment. The damaged PSII RC proteins (Dam-PSII) undergo degradation via the thylakoid membrane-bound FtsH metalloprotease, followed by posttranslational assembly of PSII. While the effect of Dam-PSII on gene regulation is described for cyanobacteria, its role in land plants is largely unknown. In this study, we reveal an intriguing retrograde signaling pathway by using the Arabidopsis (Arabidopsis thaliana) yellow variegated2-9 mutant, which expresses a mutated FtsH2 (FtsH2G267D ) metalloprotease, specifically impairing its substrate-unfolding activity. This lesion leads to the perturbation of PSII protein homeostasis (proteostasis) and the accumulation of Dam-PSII. Subsequently, this results in an up-regulation of salicylic acid (SA)-responsive genes, which is abrogated by inactivation of either an SA transporter in the chloroplast envelope membrane or extraplastidic SA signaling components as well as by removal of SA. These results suggest that the stress hormone SA, which is mainly synthesized via the chloroplast isochorismate pathway in response to the impaired PSII proteostasis, mediates the retrograde signaling. These findings reinforce the emerging view of chloroplast function toward plant stress responses and suggest SA as a potential plastid factor mediating retrograde signaling.

Original languageEnglish
Pages (from-to)2182-2197
Number of pages16
JournalPlant physiology
Volume180
Issue number4
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Salicylic Acid
salicylic acid
homeostasis
Homeostasis
Chloroplasts
Proteins
proteins
chloroplasts
Metalloproteases
metalloproteinases
Arabidopsis
Embryophyta
lesions (plant)
Thylakoids
Plastids
plant stress
embryophytes
Cyanobacteria
protein degradation
thylakoids

ASJC Scopus subject areas

  • Physiology
  • Genetics
  • Plant Science

Cite this

Duan, J., Lee, K. P., Dogra, V., Zhang, S., Liu, K., Caceres-Moreno, C., ... Kim, C. (2019). Impaired psii proteostasis promotes retrograde signaling via salicylic acid1 Plant physiology, 180(4), 2182-2197. https://doi.org/10.1104/pp.19.00483

Impaired psii proteostasis promotes retrograde signaling via salicylic acid1 . / Duan, Jianli; Lee, Keun Pyo; Dogra, Vivek; Zhang, Siyuan; Liu, Kaiwei; Caceres-Moreno, Carlos; Lv, Shanshan; Xing, Weiman; Kato, Yusuke; Sakamoto, Wataru; Liu, Renyi; Macho, Alberto P.; Kim, Chanhong.

In: Plant physiology, Vol. 180, No. 4, 01.08.2019, p. 2182-2197.

Research output: Contribution to journalArticle

Duan, J, Lee, KP, Dogra, V, Zhang, S, Liu, K, Caceres-Moreno, C, Lv, S, Xing, W, Kato, Y, Sakamoto, W, Liu, R, Macho, AP & Kim, C 2019, 'Impaired psii proteostasis promotes retrograde signaling via salicylic acid1 ', Plant physiology, vol. 180, no. 4, pp. 2182-2197. https://doi.org/10.1104/pp.19.00483
Duan J, Lee KP, Dogra V, Zhang S, Liu K, Caceres-Moreno C et al. Impaired psii proteostasis promotes retrograde signaling via salicylic acid1 Plant physiology. 2019 Aug 1;180(4):2182-2197. https://doi.org/10.1104/pp.19.00483
Duan, Jianli ; Lee, Keun Pyo ; Dogra, Vivek ; Zhang, Siyuan ; Liu, Kaiwei ; Caceres-Moreno, Carlos ; Lv, Shanshan ; Xing, Weiman ; Kato, Yusuke ; Sakamoto, Wataru ; Liu, Renyi ; Macho, Alberto P. ; Kim, Chanhong. / Impaired psii proteostasis promotes retrograde signaling via salicylic acid1 In: Plant physiology. 2019 ; Vol. 180, No. 4. pp. 2182-2197.
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