Impact of smoking on the age at diagnosis of upper tract urothelial carcinoma: Subanalysis of the Japanese Urological Association multi-institutional national database

Jun Miyazaki, Hiroyuki Nishiyama, Hiroyuki Fujimoto, Chikara Ohyama, Takuya Koie, Shiro Hinotsu, Eiji Kikuchi, Mizuaki Sakura, Junichi Inokuchi, Tomohiko Hara, Hiro omi Kanayama, Tsuneharu Miki, Kazuhiro Suzuki, Masatoshi Eto, Hiroyuki Nakanishi, Tomoharu Fukumori, Seiji Naito

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To examine the influence of smoking history on the diagnosis and other tumor characteristics of upper tract urothelial carcinoma in Japan. Methods: A total of 1509 patients with upper tract urothelial carcinoma who were diagnosed in 2005 from 348 Japanese institutions were registered using the multi-institutional national database of the Japanese Urological Association and included in this analysis. Clinical data of the patients were collected in 2011. The associations between the patients' self-reported smoking history and their age at the diagnosis of upper tract urothelial carcinoma, sex, pathological T stage and tumor grade were analyzed. Results: The mean age at the diagnosis of upper tract urothelial carcinoma was approximately 5 years earlier for the 238 current smokers than for the 618 current non-smokers (P <0.0001). Similar associations between smoking and the early diagnosis of upper tract urothelial carcinoma were shown in the sex subgroups and in subgroups stratified by pathological T stages. Among the current smokers, the age at diagnosis for the smoking ≥20 cigarettes per day group was 6.5 years lower than that of the

Original languageEnglish
Pages (from-to)1023-1027
Number of pages5
JournalInternational Journal of Urology
Volume22
Issue number11
DOIs
Publication statusPublished - Nov 1 2015

    Fingerprint

Keywords

  • Age at diagnosis
  • Japanese
  • Smoking
  • Upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Miyazaki, J., Nishiyama, H., Fujimoto, H., Ohyama, C., Koie, T., Hinotsu, S., Kikuchi, E., Sakura, M., Inokuchi, J., Hara, T., Kanayama, H. O., Miki, T., Suzuki, K., Eto, M., Nakanishi, H., Fukumori, T., & Naito, S. (2015). Impact of smoking on the age at diagnosis of upper tract urothelial carcinoma: Subanalysis of the Japanese Urological Association multi-institutional national database. International Journal of Urology, 22(11), 1023-1027. https://doi.org/10.1111/iju.12886