Impact of one-carbon metabolism-driving epitranscriptome as a therapeutic target for gastrointestinal cancer

Yu Takeda, Ryota Chijimatsu, Andrea Vecchione, Takahiro Arai, Toru Kitagawa, Ken Ofusa, Masami Yabumoto, Takaaki Hirotsu, Hidetoshi Eguchi, Yuichiro Doki, Hideshi Ishii

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

One-carbon (1C) metabolism plays a key role in biological functions linked to the folate cycle. These include nucleotide synthesis; the methylation of DNA, RNA, and proteins in the methionine cycle; and transsulfuration to maintain the redox condition of cancer stem cells in the tumor microenvironment. Recent studies have indicated that small therapeutic compounds affect the mitochondrial folate cycle, epitranscriptome (RNA methylation), and reactive oxygen species reactions in cancer cells. The epitranscriptome controls cellular biochemical reactions, but is also a platform for cell-to-cell interaction and cell transformation. We present an update of recent advances in the study of 1C metabolism related to cancer and demonstrate the areas where further research is needed. We also discuss approaches to therapeutic drug discovery using animal models and propose further steps toward developing precision cancer medicine.

Original languageEnglish
Article number7278
JournalInternational journal of molecular sciences
Volume22
Issue number14
DOIs
Publication statusPublished - Jul 2 2021
Externally publishedYes

Keywords

  • Amino acids
  • Epitranscriptome
  • Microenvironment
  • One-carbon metabolism
  • Tumor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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