Impact of maintenance therapy for patients with non-small cell lung cancer in a real-world setting

Kiyotaka Yoh, Yasushi Goto, Yoichi Naito, Kazuma Kishi, Kiyoshi Mori, Katsuyuki Hotta, Yukio Hosomi, Kazuhiko Yamada, Chiharu Tanai, Yoshio Tomizawa, Akira Inoue, Yoshinori Hasegawa, Makoto Nishio, Yasuo Ohashi, Hideo Kunitoh

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4 Citations (Scopus)

Abstract

Background: The purpose of this study was to explore the role of maintenance therapy for patients with advanced non-small cell lung cancer (NSCLC) in a realworld setting. Patients and Methods: This was a prospective observational cohort multicenter study. Eligible patients were observed from initiation of first-line platinum-based chemotherapy until final follow-up. Results: Between 2010 and 2011, a total of 864 patients were enrolled in this study. The primary study population was 396 patients who had progressive disease during observation after first-line chemotherapy without maintenance. Of these, 113 patients (29%) did not receive second-line therapy. In contrast, only 18% of patients who had progressive disease during maintenance therapy missed second-line therapy. Overall survival of patients without maintenance who received second-line therapy was similar to that of those who received maintenance, but no second-line therapy. Conclusion: Maintenance therapy for patients with advanced NSCLC might be an appropriate strategy to maximize the chance of receiving more active therapy.

Original languageEnglish
Pages (from-to)1507-1513
Number of pages7
JournalAnticancer research
Volume37
Issue number3
DOIs
Publication statusPublished - Mar 2017

Keywords

  • Maintenance therapy
  • Non-small cell lung cancer
  • Platinum-based chemotherapy
  • Second-line therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Yoh, K., Goto, Y., Naito, Y., Kishi, K., Mori, K., Hotta, K., Hosomi, Y., Yamada, K., Tanai, C., Tomizawa, Y., Inoue, A., Hasegawa, Y., Nishio, M., Ohashi, Y., & Kunitoh, H. (2017). Impact of maintenance therapy for patients with non-small cell lung cancer in a real-world setting. Anticancer research, 37(3), 1507-1513. https://doi.org/10.21873/anticanres.11478