Impact of hypertriglyceridemia on endothelial dysfunction during statin ± ezetimibe therapy in patients with coronary heart disease

Kei Yunoki, Kazufumi Nakamura, Toru Miyoshi, Kenki Enko, Motoki Kubo, Masato Murakami, Yoshiki Hata, Kunihisa Kohno, Hiroshi Morita, Kengo F. Kusano, Hiroshi Itoh

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Despite the use of statin therapy and achieving the target for low-density lipoprotein cholesterol, a substantial number of coronary events are not prevented, and residual risk factors remain unsettled. Recently, ezetimibe has been shown to reduce not only low-density lipoprotein cholesterol but also triglyceride (TG) levels. The aim of this study was to investigate the associations of residual risk factors, mainly hypertriglyceridemia, with endothelial function during statin therapy in patients with coronary heart disease and examine the effect of ezetimibe add-on therapy. A total of 109 consecutive patients with coronary heart disease during statin therapy were enrolled. Lipid profile was measured and endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery in a fasting state. Next, 32 patients with high TG levels (

Original languageEnglish
Pages (from-to)333-339
Number of pages7
JournalAmerican Journal of Cardiology
Volume108
Issue number3
DOIs
Publication statusPublished - Aug 1 2011

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypertriglyceridemia
Coronary Disease
LDL Cholesterol
Triglycerides
Brachial Artery
Therapeutics
Dilatation
Fasting
Lipids
Ezetimibe

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of hypertriglyceridemia on endothelial dysfunction during statin ± ezetimibe therapy in patients with coronary heart disease. / Yunoki, Kei; Nakamura, Kazufumi; Miyoshi, Toru; Enko, Kenki; Kubo, Motoki; Murakami, Masato; Hata, Yoshiki; Kohno, Kunihisa; Morita, Hiroshi; Kusano, Kengo F.; Itoh, Hiroshi.

In: American Journal of Cardiology, Vol. 108, No. 3, 01.08.2011, p. 333-339.

Research output: Contribution to journalArticle

Yunoki, Kei ; Nakamura, Kazufumi ; Miyoshi, Toru ; Enko, Kenki ; Kubo, Motoki ; Murakami, Masato ; Hata, Yoshiki ; Kohno, Kunihisa ; Morita, Hiroshi ; Kusano, Kengo F. ; Itoh, Hiroshi. / Impact of hypertriglyceridemia on endothelial dysfunction during statin ± ezetimibe therapy in patients with coronary heart disease. In: American Journal of Cardiology. 2011 ; Vol. 108, No. 3. pp. 333-339.
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AU - Kubo, Motoki

AU - Murakami, Masato

AU - Hata, Yoshiki

AU - Kohno, Kunihisa

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