Abstract
Purpose: The biological responses to mesh in vivo have been evaluated in some papers, but the in vivo condition of mesh and plugs have not been sufficiently evaluated. This study evaluated the endoscopic observations and histological assessments of mesh plugs using swine models. Methods: An artificial abdominal hernia was established in the porcine abdomen, and repaired using three different sizes of two types of plug, Proloop (ATRIUM Medical Corporation, Hudson, NH, USA) or Perfix (BARD Medical Division, Covington, GA, USA). The in vivo conditions of each plug were periodically observed using a laparoscope. Moreover, a histological evaluation of the plugs was performed 3 months after implantation. Results: The laparoscopic observation revealed that inversion of the plugs occurred in 10 out of 18 cases repaired with Perfix, while no case repaired with Proloop inverted. The large and medium sizes of Perfix plugs were inclined by an average of more than 30°. In addition, the triangular shape of Perfix plugs was broken and the vertical/horizontal ratio was enlarged during the observation period, while Proloop plugs shrank both vertically and horizontally. The infl ammatory cell count was significantly lower within the Proloop plugs than within Perfix plugs. Conclusion: Proloop plugs are apparently superior because they are stable even 3 months after implantation.
| Original language | English |
|---|---|
| Pages (from-to) | 1512-1518 |
| Number of pages | 7 |
| Journal | Surgery Today |
| Volume | 41 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2011 |
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Keywords
- Groin hernia
- Histological evaluation
- Laparoscopic evaluation
- Mesh plug
- Porcine
ASJC Scopus subject areas
- Surgery
Cite this
Impact of endoscopic and histological evaluations of two different types of mesh plug for a groin hernia model. / Mandai, Yasuhiro; Naito, Minoru; Hayashi, Tatsuro; Asano, Hiroaki; Ino, Hideo; Tsukuda, Kazunori; Miyoshi, Shinichiro.
In: Surgery Today, Vol. 41, No. 11, 11.2011, p. 1512-1518.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of endoscopic and histological evaluations of two different types of mesh plug for a groin hernia model
AU - Mandai, Yasuhiro
AU - Naito, Minoru
AU - Hayashi, Tatsuro
AU - Asano, Hiroaki
AU - Ino, Hideo
AU - Tsukuda, Kazunori
AU - Miyoshi, Shinichiro
PY - 2011/11
Y1 - 2011/11
N2 - Purpose: The biological responses to mesh in vivo have been evaluated in some papers, but the in vivo condition of mesh and plugs have not been sufficiently evaluated. This study evaluated the endoscopic observations and histological assessments of mesh plugs using swine models. Methods: An artificial abdominal hernia was established in the porcine abdomen, and repaired using three different sizes of two types of plug, Proloop (ATRIUM Medical Corporation, Hudson, NH, USA) or Perfix (BARD Medical Division, Covington, GA, USA). The in vivo conditions of each plug were periodically observed using a laparoscope. Moreover, a histological evaluation of the plugs was performed 3 months after implantation. Results: The laparoscopic observation revealed that inversion of the plugs occurred in 10 out of 18 cases repaired with Perfix, while no case repaired with Proloop inverted. The large and medium sizes of Perfix plugs were inclined by an average of more than 30°. In addition, the triangular shape of Perfix plugs was broken and the vertical/horizontal ratio was enlarged during the observation period, while Proloop plugs shrank both vertically and horizontally. The infl ammatory cell count was significantly lower within the Proloop plugs than within Perfix plugs. Conclusion: Proloop plugs are apparently superior because they are stable even 3 months after implantation.
AB - Purpose: The biological responses to mesh in vivo have been evaluated in some papers, but the in vivo condition of mesh and plugs have not been sufficiently evaluated. This study evaluated the endoscopic observations and histological assessments of mesh plugs using swine models. Methods: An artificial abdominal hernia was established in the porcine abdomen, and repaired using three different sizes of two types of plug, Proloop (ATRIUM Medical Corporation, Hudson, NH, USA) or Perfix (BARD Medical Division, Covington, GA, USA). The in vivo conditions of each plug were periodically observed using a laparoscope. Moreover, a histological evaluation of the plugs was performed 3 months after implantation. Results: The laparoscopic observation revealed that inversion of the plugs occurred in 10 out of 18 cases repaired with Perfix, while no case repaired with Proloop inverted. The large and medium sizes of Perfix plugs were inclined by an average of more than 30°. In addition, the triangular shape of Perfix plugs was broken and the vertical/horizontal ratio was enlarged during the observation period, while Proloop plugs shrank both vertically and horizontally. The infl ammatory cell count was significantly lower within the Proloop plugs than within Perfix plugs. Conclusion: Proloop plugs are apparently superior because they are stable even 3 months after implantation.
KW - Groin hernia
KW - Histological evaluation
KW - Laparoscopic evaluation
KW - Mesh plug
KW - Porcine
UR - http://www.scopus.com/inward/record.url?scp=84855168567&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855168567&partnerID=8YFLogxK
U2 - 10.1007/s00595-010-4520-9
DO - 10.1007/s00595-010-4520-9
M3 - Article
C2 - 21969154
AN - SCOPUS:84855168567
VL - 41
SP - 1512
EP - 1518
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
SN - 0941-1291
IS - 11
ER -