Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era

Daisaku Nakatani, Yasuhiko Sakata, Hiroya Mizuno, Masahiko Shimizu, Shinichiro Suna, Masaya Usami, Hiroshi Itoh, Yoshio Yasumura, Atsushi Hirayama, Hiroshi Takeda, Masatsugu Hori, Hiroshi Sato

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: There is little data regarding the clinical impact of diabetes mellitus (DM) on heart failure (HF) among survivors of acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. Methods and Results: The present study group comprised 4,035 survivors who underwent PCI within 24 h of the onset of symptoms. DM was an independent predictor of rehospitalization for HF by multivariate analysis (hazard ratio (HR) 1.576, P=0.010). The risk of rehospitalization for HF was similar between patients with DM who did not have an enlarged left vetricular diastolic diameter (LVDd 1c level before discharge was similar between patients with and without rehospitalization for HF (7.5±1.9% vs 7.4±1.6%, P=0.455), whereas high-sensitivity C-reactive protein (hs-CRP) was higher in patients with than without rehospitalization for HF (1.80±3.63 vs 0.75±2.03 mg/dl, P=0.001). Conclusions: DM is an independent predictor of rehospitalization for HF after AMI in the PCI era. Diabetic patients without left ventricular remodeling should be treated as a high-risk group for HF. Measurement of hs-CRP level may be useful for predicting rehospitalization because of HF in diabetic patients after AMI.

Original languageEnglish
Pages (from-to)662-666
Number of pages5
JournalCirculation Journal
Volume73
Issue number4
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

Fingerprint

Percutaneous Coronary Intervention
Survivors
Diabetes Mellitus
Heart Failure
Myocardial Infarction
C-Reactive Protein
Ventricular Remodeling
Multivariate Analysis

Keywords

  • Diabetes mellitus
  • Heart failure
  • High-sensitivity C-reactive protein
  • Myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era. / Nakatani, Daisaku; Sakata, Yasuhiko; Mizuno, Hiroya; Shimizu, Masahiko; Suna, Shinichiro; Usami, Masaya; Itoh, Hiroshi; Yasumura, Yoshio; Hirayama, Atsushi; Takeda, Hiroshi; Hori, Masatsugu; Sato, Hiroshi.

In: Circulation Journal, Vol. 73, No. 4, 04.2009, p. 662-666.

Research output: Contribution to journalArticle

Nakatani, D, Sakata, Y, Mizuno, H, Shimizu, M, Suna, S, Usami, M, Itoh, H, Yasumura, Y, Hirayama, A, Takeda, H, Hori, M & Sato, H 2009, 'Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era', Circulation Journal, vol. 73, no. 4, pp. 662-666. https://doi.org/10.1253/circj.CJ-08-0579
Nakatani, Daisaku ; Sakata, Yasuhiko ; Mizuno, Hiroya ; Shimizu, Masahiko ; Suna, Shinichiro ; Usami, Masaya ; Itoh, Hiroshi ; Yasumura, Yoshio ; Hirayama, Atsushi ; Takeda, Hiroshi ; Hori, Masatsugu ; Sato, Hiroshi. / Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era. In: Circulation Journal. 2009 ; Vol. 73, No. 4. pp. 662-666.
@article{31de38a5113d4d1aaeab37484f1a422b,
title = "Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era",
abstract = "Background: There is little data regarding the clinical impact of diabetes mellitus (DM) on heart failure (HF) among survivors of acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. Methods and Results: The present study group comprised 4,035 survivors who underwent PCI within 24 h of the onset of symptoms. DM was an independent predictor of rehospitalization for HF by multivariate analysis (hazard ratio (HR) 1.576, P=0.010). The risk of rehospitalization for HF was similar between patients with DM who did not have an enlarged left vetricular diastolic diameter (LVDd 1c level before discharge was similar between patients with and without rehospitalization for HF (7.5±1.9{\%} vs 7.4±1.6{\%}, P=0.455), whereas high-sensitivity C-reactive protein (hs-CRP) was higher in patients with than without rehospitalization for HF (1.80±3.63 vs 0.75±2.03 mg/dl, P=0.001). Conclusions: DM is an independent predictor of rehospitalization for HF after AMI in the PCI era. Diabetic patients without left ventricular remodeling should be treated as a high-risk group for HF. Measurement of hs-CRP level may be useful for predicting rehospitalization because of HF in diabetic patients after AMI.",
keywords = "Diabetes mellitus, Heart failure, High-sensitivity C-reactive protein, Myocardial infarction",
author = "Daisaku Nakatani and Yasuhiko Sakata and Hiroya Mizuno and Masahiko Shimizu and Shinichiro Suna and Masaya Usami and Hiroshi Itoh and Yoshio Yasumura and Atsushi Hirayama and Hiroshi Takeda and Masatsugu Hori and Hiroshi Sato",
year = "2009",
month = "4",
doi = "10.1253/circj.CJ-08-0579",
language = "English",
volume = "73",
pages = "662--666",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "4",

}

TY - JOUR

T1 - Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era

AU - Nakatani, Daisaku

AU - Sakata, Yasuhiko

AU - Mizuno, Hiroya

AU - Shimizu, Masahiko

AU - Suna, Shinichiro

AU - Usami, Masaya

AU - Itoh, Hiroshi

AU - Yasumura, Yoshio

AU - Hirayama, Atsushi

AU - Takeda, Hiroshi

AU - Hori, Masatsugu

AU - Sato, Hiroshi

PY - 2009/4

Y1 - 2009/4

N2 - Background: There is little data regarding the clinical impact of diabetes mellitus (DM) on heart failure (HF) among survivors of acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. Methods and Results: The present study group comprised 4,035 survivors who underwent PCI within 24 h of the onset of symptoms. DM was an independent predictor of rehospitalization for HF by multivariate analysis (hazard ratio (HR) 1.576, P=0.010). The risk of rehospitalization for HF was similar between patients with DM who did not have an enlarged left vetricular diastolic diameter (LVDd 1c level before discharge was similar between patients with and without rehospitalization for HF (7.5±1.9% vs 7.4±1.6%, P=0.455), whereas high-sensitivity C-reactive protein (hs-CRP) was higher in patients with than without rehospitalization for HF (1.80±3.63 vs 0.75±2.03 mg/dl, P=0.001). Conclusions: DM is an independent predictor of rehospitalization for HF after AMI in the PCI era. Diabetic patients without left ventricular remodeling should be treated as a high-risk group for HF. Measurement of hs-CRP level may be useful for predicting rehospitalization because of HF in diabetic patients after AMI.

AB - Background: There is little data regarding the clinical impact of diabetes mellitus (DM) on heart failure (HF) among survivors of acute myocardial infarction (AMI) in the percutaneous coronary intervention (PCI) era. Methods and Results: The present study group comprised 4,035 survivors who underwent PCI within 24 h of the onset of symptoms. DM was an independent predictor of rehospitalization for HF by multivariate analysis (hazard ratio (HR) 1.576, P=0.010). The risk of rehospitalization for HF was similar between patients with DM who did not have an enlarged left vetricular diastolic diameter (LVDd 1c level before discharge was similar between patients with and without rehospitalization for HF (7.5±1.9% vs 7.4±1.6%, P=0.455), whereas high-sensitivity C-reactive protein (hs-CRP) was higher in patients with than without rehospitalization for HF (1.80±3.63 vs 0.75±2.03 mg/dl, P=0.001). Conclusions: DM is an independent predictor of rehospitalization for HF after AMI in the PCI era. Diabetic patients without left ventricular remodeling should be treated as a high-risk group for HF. Measurement of hs-CRP level may be useful for predicting rehospitalization because of HF in diabetic patients after AMI.

KW - Diabetes mellitus

KW - Heart failure

KW - High-sensitivity C-reactive protein

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=65649121869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65649121869&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-08-0579

DO - 10.1253/circj.CJ-08-0579

M3 - Article

C2 - 19225202

AN - SCOPUS:65649121869

VL - 73

SP - 662

EP - 666

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 4

ER -