Impact of compression, physical aging, and freezing rate on the crystallization characteristics of an amorphous sugar matrix

Koreyoshi Imamura, Kohshi Kinugawa, Ryo Kagotani, Mayo Nomura, Kazuhiro Nakanishi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Amorphous matrices made up of sugar molecules, are frequently used in food and pharmaceutical industries. A drawback to their use is that they are susceptible to collapse, as a result of water uptake and an increase in temperature and subsequently crystallize. Herein, the crystallization characteristics of amorphous sugar (sucrose and α-lactose) preparations were analyzed, with the purpose of obtaining knowledge that could lead to the prediction of how long the amorphous state is retained under various conditions. The impact of compression, physical aging and freezing rate on the induction period (t ind) for crystallization were examined. Freeze-dried sugar samples were compressed at 74 or 443 MPa (5 min) and then rehumidified at specified RHs. Some freeze-dried sucrose samples were physically aged, and alternatively freeze-drying was conducted under different conditions. The isothermal crystallization of the prepared samples at different temperatures (T), the glass transition and the crystallization temperature (T cry) were measured, using differential scanning calorimetry. The compression markedly decreased the t ind, while significantly lowered the hygroscopicity. Physical aging and slower-freezing also shortened the t ind. The t ind was found to be correlated exclusively with (T cry-T), regardless of rehumidification, compression, sugar type, physical aging and freezing rate in the freeze-drying process.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalJournal of Food Engineering
Volume112
Issue number4
DOIs
Publication statusPublished - Oct 2012

Fingerprint

crystallization
Crystallization
Freezing
freezing
sugars
Freeze Drying
freeze drying
Sucrose
sucrose
Wettability
glass transition
temperature
Temperature
Transition Temperature
Food Industry
Differential Scanning Calorimetry
Drug Industry
Lactose
differential scanning calorimetry
sampling

Keywords

  • Aging
  • Amorphous sugar
  • Compression
  • Crystallization
  • Induction period

ASJC Scopus subject areas

  • Food Science

Cite this

Impact of compression, physical aging, and freezing rate on the crystallization characteristics of an amorphous sugar matrix. / Imamura, Koreyoshi; Kinugawa, Kohshi; Kagotani, Ryo; Nomura, Mayo; Nakanishi, Kazuhiro.

In: Journal of Food Engineering, Vol. 112, No. 4, 10.2012, p. 313-318.

Research output: Contribution to journalArticle

Imamura, Koreyoshi ; Kinugawa, Kohshi ; Kagotani, Ryo ; Nomura, Mayo ; Nakanishi, Kazuhiro. / Impact of compression, physical aging, and freezing rate on the crystallization characteristics of an amorphous sugar matrix. In: Journal of Food Engineering. 2012 ; Vol. 112, No. 4. pp. 313-318.
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