Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor

Yuki Moritou, Fusao Ikeda, Yoshiaki Iwasaki, Nobuyuki Baba, Kouichi Takaguchi, Tomonori Senoh, Takuya Nagano, Yasuto Takeuchi, Tetsuya Yasunaka, Hideki Ohnishi, Yasuhiro Miyake, Akinobu Takaki, Kazuhiro Nouso, Kazuhide Yamamoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The impact of hepatic steatosis on interferon therapy for patients with chronic hepatitis C (CHC) has been associated with single-nucleotide polymorphisms (SNP) of IL28B, patatin-like phospholipase domain-containing protein 3 (PNPLA3), and low-density lipoprotein (LDL) receptor. Whether this holds true for Japanese patients, however, remains unresolved. The present study prospectively enrolled 226 Japanese patients with CHC, and investigated the impact of hepatic steatosis and its related SNPs, including rs8099917 of IL28B, rs738409 of PNPLA3, and rs14158 of LDL receptor, on outcomes of peg-interferon and ribavirin therapy. In multivariate logistic regression analysis, significant factors affecting the severity of hepatic steatosis were high body mass index and the minor alleles of IL28B SNP (p=0.020 and 0.039, respectively). The risk alleles of PNPLA3 SNP also showed weak association (p=0.059). Severe steatosis and the minor alleles of IL28B SNP were significantly associated with null or partial virological response in patients with HCV genotype 1, as were female gender, and low LDL cholesterol (p=0.049, and

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalActa Medica Okayama
Volume68
Issue number1
Publication statusPublished - 2014

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Phospholipases
LDL Receptors
Genetic Polymorphisms
Chronic Hepatitis C
Polymorphism
Single Nucleotide Polymorphism
Nucleotides
Liver
Interferons
Alleles
Proteins
Ribavirin
Therapeutics
Regression analysis
LDL Cholesterol
Logistics
Body Mass Index
Logistic Models
Genotype
Regression Analysis

Keywords

  • Genetic polymorphism
  • HCV
  • Hepatic steatosis
  • Interferon

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor. / Moritou, Yuki; Ikeda, Fusao; Iwasaki, Yoshiaki; Baba, Nobuyuki; Takaguchi, Kouichi; Senoh, Tomonori; Nagano, Takuya; Takeuchi, Yasuto; Yasunaka, Tetsuya; Ohnishi, Hideki; Miyake, Yasuhiro; Takaki, Akinobu; Nouso, Kazuhiro; Yamamoto, Kazuhide.

In: Acta Medica Okayama, Vol. 68, No. 1, 2014, p. 17-22.

Research output: Contribution to journalArticle

Moritou, Yuki ; Ikeda, Fusao ; Iwasaki, Yoshiaki ; Baba, Nobuyuki ; Takaguchi, Kouichi ; Senoh, Tomonori ; Nagano, Takuya ; Takeuchi, Yasuto ; Yasunaka, Tetsuya ; Ohnishi, Hideki ; Miyake, Yasuhiro ; Takaki, Akinobu ; Nouso, Kazuhiro ; Yamamoto, Kazuhide. / Impact of Comorbid Hepatic Steatosis on Treatment of Chronic Hepatitis C in Japanese Patients and the Relationship with Genetic Polymorphism of IL28B, PNPLA3 and LDL Receptor. In: Acta Medica Okayama. 2014 ; Vol. 68, No. 1. pp. 17-22.
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