Impact of chemotherapy on cognitive functioning in older patients with HER2-positive breast cancer: a sub-study in the RESPECT trial

Yasuhiro Hagiwara, Masataka Sawaki, Yukari Uemura, Takuya Kawahara, Kojiro Shimozuma, Yasuo Ohashi, Masato Takahashi, Tsuyoshi Saito, Shinichi Baba, Kokoro Kobayashi, Hirofumi Mukai, Naruto Taira

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To investigate whether postoperative adjuvant trastuzumab plus chemotherapy negatively affected cognitive functioning during the post-chemotherapy period compared with trastuzumab monotherapy in older patients with HER2-positive breast cancer. Methods: In the randomized RESPECT trial, women aged between 70 and 80 years with HER2-positive, stage I to IIIA invasive breast cancer who underwent curative operation were randomly assigned to receive either 1-year trastuzumab monotherapy or 1-year trastuzumab plus chemotherapy. Cognitive functioning was assessed using the Mini-Mental State Examination (MMSE) test at enrollment and 1 and 3 years after initiation of the protocol treatment. The primary outcome was change in the MMSE total score from baseline. Secondary outcomes included prevalence of suspected mild cognitive impairment (MMSE total score < 28) and suspected dementia (MMSE total score < 24). Results: The analytical population consisted of 29 and 26 patients in the trastuzumab monotherapy and trastuzumab plus chemotherapy groups, respectively. The group differences in mean changes of the MMSE total score were 0.6 (95% confidence interval [CI] − 0.3 to 1.6) at 1 year and 0.9 (95% CI − 1.0 to 2.8) at 3 years (P = 0.136 for the group difference pooling the two visits). The prevalence of suspected mild cognitive impairment at 3 years was 41.7% in the trastuzumab monotherapy group and 28.6% in the trastuzumab plus chemotherapy group (P = 0.548). Conclusion: This randomized sub-study did not show worse cognitive functioning during the post-chemotherapy period with trastuzumab plus chemotherapy than with trastuzumab monotherapy in older patients with HER2-positive breast cancer. Trial registration number: NCT01104935 (first posted April 16, 2010).

Original languageEnglish
Pages (from-to)675-683
Number of pages9
JournalBreast Cancer Research and Treatment
Volume188
Issue number3
DOIs
Publication statusPublished - Aug 2021
Externally publishedYes

Keywords

  • Adjuvant chemotherapy
  • Adjuvant trastuzumab
  • Cognitive functioning
  • HER2-positive breast cancer
  • Older patients

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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