Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction

Hiroya Mizuno, Hiroshi Sato, Yasuhiko Sakata, Yozo Ohnishi, Eiji Hishida, Kunihiro Kinjo, Daisaku Nakatani, Masahiko Shimizu, Hiroya Kondo, Toshihiro Tanaka, Kouichi Ozaki, Atsushi Hirayama, Hiroshi Ito, Kinya Otsu, Masatsugu Hori

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Abstract

Although previous epidemiologic studies have suggested an association between the onset of myocardial infarction (MI) and some genetic variations, the impact of these variants on recurrent cardiovascular events after MI has not been fully elucidated. We genotyped 87 polymorphisms of 73 atherosclerosis- related genes in consecutive acute MI patients registered in the Osaka Acute Coronary Insufficiency Study and compared the incidence of death and major adverse cardiac events (MACE) among the polymorphisms of each gene. After initial screening in 507 patients, we selected nine polymorphisms for screening in all 1586 patients. Multivariate Cox regression analysis revealed that G allele carriers at the position 252 of the lymphotoxin alpha (LTA) gene were independently associated with an increased risk of death (hazard ratio [HR]: 2.46; 95% CI: 1.24-4.86). In conclusion, a 252G allele of LTA is associated with an increased risk of death after AMI and may be a useful genetic predictor.

Original languageEnglish
Pages (from-to)400-405
Number of pages6
JournalAtherosclerosis
Volume185
Issue number2
DOIs
Publication statusPublished - Apr 2006
Externally publishedYes

Keywords

  • Lymphotoxin alpha
  • Myocardial infarction
  • Polymorphism
  • Prognosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Mizuno, H., Sato, H., Sakata, Y., Ohnishi, Y., Hishida, E., Kinjo, K., Nakatani, D., Shimizu, M., Kondo, H., Tanaka, T., Ozaki, K., Hirayama, A., Ito, H., Otsu, K., & Hori, M. (2006). Impact of atherosclerosis-related gene polymorphisms on mortality and recurrent events after myocardial infarction. Atherosclerosis, 185(2), 400-405. https://doi.org/10.1016/j.atherosclerosis.2005.06.020