Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline [123I]Ioflupane single photon emission computed tomography/computed tomography

Rudolf A. Werner, Constantin Lapa, Sara Sheikhbahaei, Charles Marcus, Lilja B. Solnes, Yong Du, Jeffrey P. Leal, Andreas K. Buck, Takahiro Higuchi, Steven P. Rowe, Mehrbod S. Javadi

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Studies investigating the age-related impact on dopamine transporter binding have previously omitted the use of attenuation correction by computed tomography (CT). We aimed to explore the impact of age and gender on dopamine transporter binding on [I]Ioflupane single photon emission CT (SPECT) imaging with simultaneously acquired CT. METHODS: Three hundred forty-two patients with clinically uncertain parkinsonian syndrome underwent [I]-Ioflupane SPECT/CT with CT-based attenuation correction. Two nuclear medicine physicians independently performed a visual evaluation of all scans and only visibly normal scans were included for further analysis. Moreover, the results of a fully automatic semiquantitative evaluation method were recorded. Thereafter, the obtained [I]Ioflupane binding ratio and the hemispheric asymmetry index were correlated with age and sex. RESULTS: Patient age range was 41-80 years with a balanced distribution over decades. Of 342 patients, 133 (38.9%, 66 females, median age, 64 years) were considered visually normal by both observers on the SPECT/CT images. A significant inverse correlation between age and [I]Ioflupane binding ratios in the striata (R = -0.38; P < 0.001), putamina (R = -0.39; P < 0.001) and caudate nuclei (R = -0.3; P < 0.001) was demonstrated. Linear regression of all included subjects demonstrated an average decrease of 0.19 per decade in the striatal binding ratio (6.6%). No significant sex differences were found in striatal binding ratios (P = 0.86). Moreover, no significant correlation was observed between age and striatal asymmetry index (r = 0.12; P = 0.16). CONCLUSION: In the present largest single-center analysis investigating [I]Ioflupane SPECT/CT in patients with clinical uncertain parkinsonian syndrome, a dopamine transporter loss of 6.6% per decade in visually normal scans was recorded.

Original languageEnglish
Pages (from-to)1001-1004
Number of pages4
JournalNuclear medicine communications
Volume40
Issue number10
DOIs
Publication statusPublished - Oct 1 2019

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Single-Photon Emission-Computed Tomography
Corpus Striatum
Dopamine Plasma Membrane Transport Proteins
Tomography
Parkinsonian Disorders
Caudate Nucleus
Nuclear Medicine
Sex Characteristics
Linear Models
Single Photon Emission Computed Tomography Computed Tomography
ioflupane
Physicians

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline [123I]Ioflupane single photon emission computed tomography/computed tomography. / Werner, Rudolf A.; Lapa, Constantin; Sheikhbahaei, Sara; Marcus, Charles; Solnes, Lilja B.; Du, Yong; Leal, Jeffrey P.; Buck, Andreas K.; Higuchi, Takahiro; Rowe, Steven P.; Javadi, Mehrbod S.

In: Nuclear medicine communications, Vol. 40, No. 10, 01.10.2019, p. 1001-1004.

Research output: Contribution to journalArticle

Werner, Rudolf A. ; Lapa, Constantin ; Sheikhbahaei, Sara ; Marcus, Charles ; Solnes, Lilja B. ; Du, Yong ; Leal, Jeffrey P. ; Buck, Andreas K. ; Higuchi, Takahiro ; Rowe, Steven P. ; Javadi, Mehrbod S. / Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline [123I]Ioflupane single photon emission computed tomography/computed tomography. In: Nuclear medicine communications. 2019 ; Vol. 40, No. 10. pp. 1001-1004.
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abstract = "OBJECTIVES: Studies investigating the age-related impact on dopamine transporter binding have previously omitted the use of attenuation correction by computed tomography (CT). We aimed to explore the impact of age and gender on dopamine transporter binding on [I]Ioflupane single photon emission CT (SPECT) imaging with simultaneously acquired CT. METHODS: Three hundred forty-two patients with clinically uncertain parkinsonian syndrome underwent [I]-Ioflupane SPECT/CT with CT-based attenuation correction. Two nuclear medicine physicians independently performed a visual evaluation of all scans and only visibly normal scans were included for further analysis. Moreover, the results of a fully automatic semiquantitative evaluation method were recorded. Thereafter, the obtained [I]Ioflupane binding ratio and the hemispheric asymmetry index were correlated with age and sex. RESULTS: Patient age range was 41-80 years with a balanced distribution over decades. Of 342 patients, 133 (38.9{\%}, 66 females, median age, 64 years) were considered visually normal by both observers on the SPECT/CT images. A significant inverse correlation between age and [I]Ioflupane binding ratios in the striata (R = -0.38; P < 0.001), putamina (R = -0.39; P < 0.001) and caudate nuclei (R = -0.3; P < 0.001) was demonstrated. Linear regression of all included subjects demonstrated an average decrease of 0.19 per decade in the striatal binding ratio (6.6{\%}). No significant sex differences were found in striatal binding ratios (P = 0.86). Moreover, no significant correlation was observed between age and striatal asymmetry index (r = 0.12; P = 0.16). CONCLUSION: In the present largest single-center analysis investigating [I]Ioflupane SPECT/CT in patients with clinical uncertain parkinsonian syndrome, a dopamine transporter loss of 6.6{\%} per decade in visually normal scans was recorded.",
author = "Werner, {Rudolf A.} and Constantin Lapa and Sara Sheikhbahaei and Charles Marcus and Solnes, {Lilja B.} and Yong Du and Leal, {Jeffrey P.} and Buck, {Andreas K.} and Takahiro Higuchi and Rowe, {Steven P.} and Javadi, {Mehrbod S.}",
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T1 - Impact of aging on semiquantitative uptake parameters in normal rated clinical baseline [123I]Ioflupane single photon emission computed tomography/computed tomography

AU - Werner, Rudolf A.

AU - Lapa, Constantin

AU - Sheikhbahaei, Sara

AU - Marcus, Charles

AU - Solnes, Lilja B.

AU - Du, Yong

AU - Leal, Jeffrey P.

AU - Buck, Andreas K.

AU - Higuchi, Takahiro

AU - Rowe, Steven P.

AU - Javadi, Mehrbod S.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - OBJECTIVES: Studies investigating the age-related impact on dopamine transporter binding have previously omitted the use of attenuation correction by computed tomography (CT). We aimed to explore the impact of age and gender on dopamine transporter binding on [I]Ioflupane single photon emission CT (SPECT) imaging with simultaneously acquired CT. METHODS: Three hundred forty-two patients with clinically uncertain parkinsonian syndrome underwent [I]-Ioflupane SPECT/CT with CT-based attenuation correction. Two nuclear medicine physicians independently performed a visual evaluation of all scans and only visibly normal scans were included for further analysis. Moreover, the results of a fully automatic semiquantitative evaluation method were recorded. Thereafter, the obtained [I]Ioflupane binding ratio and the hemispheric asymmetry index were correlated with age and sex. RESULTS: Patient age range was 41-80 years with a balanced distribution over decades. Of 342 patients, 133 (38.9%, 66 females, median age, 64 years) were considered visually normal by both observers on the SPECT/CT images. A significant inverse correlation between age and [I]Ioflupane binding ratios in the striata (R = -0.38; P < 0.001), putamina (R = -0.39; P < 0.001) and caudate nuclei (R = -0.3; P < 0.001) was demonstrated. Linear regression of all included subjects demonstrated an average decrease of 0.19 per decade in the striatal binding ratio (6.6%). No significant sex differences were found in striatal binding ratios (P = 0.86). Moreover, no significant correlation was observed between age and striatal asymmetry index (r = 0.12; P = 0.16). CONCLUSION: In the present largest single-center analysis investigating [I]Ioflupane SPECT/CT in patients with clinical uncertain parkinsonian syndrome, a dopamine transporter loss of 6.6% per decade in visually normal scans was recorded.

AB - OBJECTIVES: Studies investigating the age-related impact on dopamine transporter binding have previously omitted the use of attenuation correction by computed tomography (CT). We aimed to explore the impact of age and gender on dopamine transporter binding on [I]Ioflupane single photon emission CT (SPECT) imaging with simultaneously acquired CT. METHODS: Three hundred forty-two patients with clinically uncertain parkinsonian syndrome underwent [I]-Ioflupane SPECT/CT with CT-based attenuation correction. Two nuclear medicine physicians independently performed a visual evaluation of all scans and only visibly normal scans were included for further analysis. Moreover, the results of a fully automatic semiquantitative evaluation method were recorded. Thereafter, the obtained [I]Ioflupane binding ratio and the hemispheric asymmetry index were correlated with age and sex. RESULTS: Patient age range was 41-80 years with a balanced distribution over decades. Of 342 patients, 133 (38.9%, 66 females, median age, 64 years) were considered visually normal by both observers on the SPECT/CT images. A significant inverse correlation between age and [I]Ioflupane binding ratios in the striata (R = -0.38; P < 0.001), putamina (R = -0.39; P < 0.001) and caudate nuclei (R = -0.3; P < 0.001) was demonstrated. Linear regression of all included subjects demonstrated an average decrease of 0.19 per decade in the striatal binding ratio (6.6%). No significant sex differences were found in striatal binding ratios (P = 0.86). Moreover, no significant correlation was observed between age and striatal asymmetry index (r = 0.12; P = 0.16). CONCLUSION: In the present largest single-center analysis investigating [I]Ioflupane SPECT/CT in patients with clinical uncertain parkinsonian syndrome, a dopamine transporter loss of 6.6% per decade in visually normal scans was recorded.

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