Impact and relevance of alcohol dehydrogenase enantioselectivities on biotechnological applications

Afifa Ayu Koesoema, Daron M. Standley, Toshiya Senda, Tomoko Matsuda

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Alcohol dehydrogenases (ADHs) catalyze the reversible reduction of a carbonyl group to its corresponding alcohol. ADHs are widely employed for organic synthesis due to their lack of harm to the environment, broad substrate acceptance, and high enantioselectivity. This review focuses on the impact and relevance of ADH enantioselectivities on their biotechnological application. Stereoselective ADHs are beneficial to reduce challenging ketones such as ketones owning two bulky substituents or similar-sized substituents to the carbonyl carbon. Meanwhile, in cascade reactions, non-stereoselective ADHs can be utilized for the quantitative oxidation of racemic alcohol to ketone and dynamic kinetic resolution.

Original languageEnglish
Pages (from-to)2897-2909
Number of pages13
JournalApplied Microbiology and Biotechnology
Volume104
Issue number7
DOIs
Publication statusPublished - Apr 1 2020
Externally publishedYes

Keywords

  • Alcohol dehydrogenase
  • Asymmetric reduction
  • Cascade
  • Enantioselectivity
  • Enzyme engineering
  • Pharmaceutical intermediate

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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