Immuohistochemical study in lesions referred to as “blastoma” in various organs

Koichi Mandai, Shosuke Moriwaki, Hiroyoshi Doihara, Yoshinobu Nakanishi, Makoto Motoi

Research output: Contribution to journalArticle

Abstract

The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalJapanese Journal of National Medical Services
Volume44
Issue number7
DOIs
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Pulmonary Blastoma
Mesodermal Mixed Tumor
Hepatoblastoma
Wilms Tumor
Metaplasia
Neoplasms
Staining and Labeling

Keywords

  • hepatoblastoma
  • immunohistochemistry
  • mesodermal mixed tumor
  • nephroblastoma
  • pulmonary blastoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immuohistochemical study in lesions referred to as “blastoma” in various organs. / Mandai, Koichi; Moriwaki, Shosuke; Doihara, Hiroyoshi; Nakanishi, Yoshinobu; Motoi, Makoto.

In: Japanese Journal of National Medical Services, Vol. 44, No. 7, 1990, p. 711-716.

Research output: Contribution to journalArticle

Mandai, Koichi ; Moriwaki, Shosuke ; Doihara, Hiroyoshi ; Nakanishi, Yoshinobu ; Motoi, Makoto. / Immuohistochemical study in lesions referred to as “blastoma” in various organs. In: Japanese Journal of National Medical Services. 1990 ; Vol. 44, No. 7. pp. 711-716.
@article{06869f08a29949bba84cab861d2839da,
title = "Immuohistochemical study in lesions referred to as “blastoma” in various organs",
abstract = "The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.",
keywords = "hepatoblastoma, immunohistochemistry, mesodermal mixed tumor, nephroblastoma, pulmonary blastoma",
author = "Koichi Mandai and Shosuke Moriwaki and Hiroyoshi Doihara and Yoshinobu Nakanishi and Makoto Motoi",
year = "1990",
doi = "10.11261/iryo1946.44.711",
language = "English",
volume = "44",
pages = "711--716",
journal = "IRYO - Japanese Journal of National Medical Services",
issn = "0021-1699",
publisher = "Japanese Society of National Medical Services",
number = "7",

}

TY - JOUR

T1 - Immuohistochemical study in lesions referred to as “blastoma” in various organs

AU - Mandai, Koichi

AU - Moriwaki, Shosuke

AU - Doihara, Hiroyoshi

AU - Nakanishi, Yoshinobu

AU - Motoi, Makoto

PY - 1990

Y1 - 1990

N2 - The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.

AB - The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.

KW - hepatoblastoma

KW - immunohistochemistry

KW - mesodermal mixed tumor

KW - nephroblastoma

KW - pulmonary blastoma

UR - http://www.scopus.com/inward/record.url?scp=84998336415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84998336415&partnerID=8YFLogxK

U2 - 10.11261/iryo1946.44.711

DO - 10.11261/iryo1946.44.711

M3 - Article

VL - 44

SP - 711

EP - 716

JO - IRYO - Japanese Journal of National Medical Services

JF - IRYO - Japanese Journal of National Medical Services

SN - 0021-1699

IS - 7

ER -