Abstract
The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.
| Original language | English |
|---|---|
| Pages (from-to) | 711-716 |
| Number of pages | 6 |
| Journal | Japanese Journal of National Medical Services |
| Volume | 44 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1990 |
| Externally published | Yes |
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Keywords
- hepatoblastoma
- immunohistochemistry
- mesodermal mixed tumor
- nephroblastoma
- pulmonary blastoma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Immuohistochemical study in lesions referred to as “blastoma” in various organs. / Mandai, Koichi; Moriwaki, Shosuke; Doihara, Hiroyoshi; Nakanishi, Yoshinobu; Motoi, Makoto.
In: Japanese Journal of National Medical Services, Vol. 44, No. 7, 1990, p. 711-716.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immuohistochemical study in lesions referred to as “blastoma” in various organs
AU - Mandai, Koichi
AU - Moriwaki, Shosuke
AU - Doihara, Hiroyoshi
AU - Nakanishi, Yoshinobu
AU - Motoi, Makoto
PY - 1990
Y1 - 1990
N2 - The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.
AB - The immunohistochemical staining patterns of nephroblastoma, hepatoblastoma and pulmonary blastoma with special reference to mixed mesodermal tumors of genital tract were studied for markers of epithelial and mesenchymal differentiation to clarify their phenotypic nature and, possibly, their histogenesis. The pulmonary blastoma resembled adult mixed mesodermal tumor both in the morphological and immunohistochemical characteristics, demonstrating that pulmonary blastomas are mixed tumors with origin from a primitive pluripotential mesenchymal cell. In nephroblastoma the blastemal cells showed S-100 immunoreactivity. The 78-year-old female with hepatocellular carcinomal transformed into hepatoblastoma suggested the possibility that a tumor with endodermal origin would show dedifferentiation or metaplasia to a mesenchymal tissue.
KW - hepatoblastoma
KW - immunohistochemistry
KW - mesodermal mixed tumor
KW - nephroblastoma
KW - pulmonary blastoma
UR - http://www.scopus.com/inward/record.url?scp=84998336415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84998336415&partnerID=8YFLogxK
U2 - 10.11261/iryo1946.44.711
DO - 10.11261/iryo1946.44.711
M3 - Article
VL - 44
SP - 711
EP - 716
JO - IRYO - Japanese Journal of National Medical Services
JF - IRYO - Japanese Journal of National Medical Services
SN - 0021-1699
IS - 7
ER -