Immunotherapy in Transplantation

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mesenchymal stem cells (MSCs) have been isolated from bone marrow and various organs and tissues. Nowadays, a large number of tissue regeneration studies using MSCs have been reported because of their multiple differentiation ability. Furthermore, systemic MSC transplantation has been gradually considered as a promising approach for intractable diseases such as autoimmune disease, because of their immunomodulation properties. These remarkable functions are not limited to MSCs from bone marrow or adipose tissue, but also from dental tissues including dental pulp, periodontal ligament, and gingiva. This review first overviews the accumulated evidence about the immunomodulation properties of MSCs, with a focus on dental tissue derived-MSC and their potential application for immunotherapy in dentistry.

Original languageEnglish
Title of host publicationStem Cell Biology and Tissue Engineering in Dental Sciences
PublisherElsevier Inc.
Pages831-839
Number of pages9
ISBN (Print)9780123977786, 9780123971579
DOIs
Publication statusPublished - Nov 13 2014

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Keywords

  • Dental pulp stem cells
  • Gingival mesenchymal stem cells
  • Immunomodulation
  • Mesenchymal stem cells
  • Periodontal ligament stem cells
  • Regulatory T-cells
  • T-helper type 17 cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Akiyama, K., Hara, E., & Kuboki, T. (2014). Immunotherapy in Transplantation. In Stem Cell Biology and Tissue Engineering in Dental Sciences (pp. 831-839). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397157-9.00068-0