Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Lizomar J.M.P. Moia; Hideki Matsui; Guilherme A.M. de Barros; Kazuhito Tomizawa; Kazuhiro Miyamoto; Yoshihiro Kuwata; Masaaki Tokuda; Toshifumi Itano; Osamu Hatase

doi:10.1016/0006-8993(94)91138-X

Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Lizomar J.M.P. Moia, Hideki Matsui, Guilherme A.M. de Barros, Kazuhito Tomizawa, Kazuhiro Miyamoto, Yoshihiro Kuwata, Masaaki Tokuda, Toshifumi Itano, Osamu Hatase

Research output: Contribution to journal › Article

49 Citations (Scopus)

Abstract

Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

Original language	English
Pages (from-to)	337-341
Number of pages	5
Journal	Brain Research
Volume	648
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)91138-X
Publication status	Published - Jun 20 1994

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Keywords

Calcineurin
Cyclosporin A
FK506
Hippocampus
Immunosuppressant
Kindling
Neocortex
Rat brain

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

Cite this

Moia, L. J. M. P., Matsui, H., de Barros, G. A. M., Tomizawa, K., Miyamoto, K., Kuwata, Y., Tokuda, M., Itano, T., & Hatase, O. (1994). Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. Brain Research, 648(2), 337-341. https://doi.org/10.1016/0006-8993(94)91138-X

Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. / Moia, Lizomar J.M.P.; Matsui, Hideki; de Barros, Guilherme A.M.; Tomizawa, Kazuhito; Miyamoto, Kazuhiro; Kuwata, Yoshihiro; Tokuda, Masaaki; Itano, Toshifumi; Hatase, Osamu.

In: Brain Research, Vol. 648, No. 2, 20.06.1994, p. 337-341.

Research output: Contribution to journal › Article

Moia, Lizomar J.M.P. ; Matsui, Hideki ; de Barros, Guilherme A.M. ; Tomizawa, Kazuhito ; Miyamoto, Kazuhiro ; Kuwata, Yoshihiro ; Tokuda, Masaaki ; Itano, Toshifumi ; Hatase, Osamu. / Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. In: Brain Research. 1994 ; Vol. 648, No. 2. pp. 337-341.

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Access to Document

10.1016/0006-8993(94)91138-X