Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat

Lizomar J.M.P. Moia, Hideki Matsui, Guilherme A.M. de Barros, Kazuhito Tomizawa, Kazuhiro Miyamoto, Yoshihiro Kuwata, Masaaki Tokuda, Toshifumi Itano, Osamu Hatase

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Abstract

Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalBrain Research
Volume648
Issue number2
DOIs
Publication statusPublished - Jun 20 1994

Keywords

  • Calcineurin
  • Cyclosporin A
  • FK506
  • Hippocampus
  • Immunosuppressant
  • Kindling
  • Neocortex
  • Rat brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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    Moia, L. J. M. P., Matsui, H., de Barros, G. A. M., Tomizawa, K., Miyamoto, K., Kuwata, Y., Tokuda, M., Itano, T., & Hatase, O. (1994). Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat. Brain Research, 648(2), 337-341. https://doi.org/10.1016/0006-8993(94)91138-X