@article{4f2ba231f5bc4e09840bb013cf566fd9,
title = "Immunosupressants and calcineurin inhibitors, cyclosporin A and FK506, reversibly inhibit epileptogenesis in amygdaloid kindled rat",
abstract = "Calcineurin (CaN) immunoreactivity and content increased markedly in kindled rat brain, and this increment was due to CaN in the membrane fraction. Investigation of the effects of cyclosporin A and FK506 (immunosuppressants which inhibit CaN activity in T lymphcytes) in the kindling phenomena showed that the kindling stage progression was reversibly blocked by these drugs. These findings suggest that calcineurin may play an essential role in acquiring epileptogenesis in kindling.",
keywords = "Calcineurin, Cyclosporin A, FK506, Hippocampus, Immunosuppressant, Kindling, Neocortex, Rat brain",
author = "Moia, {Lizomar J.M.P.} and Hideki Matsui and {de Barros}, {Guilherme A.M.} and Kazuhito Tomizawa and Kazuhiro Miyamoto and Yoshihiro Kuwata and Masaaki Tokuda and Toshifumi Itano and Osamu Hatase",
note = "Funding Information: We would like to express our special thanks to Dr. T.H. Murakami in the Department of Biology and Dr. T. Negi in the Department of Sports Medicine in The Kagawa Medical School for their technical instruction and support to prepare kindling rats. We also thank to Dr. Najma Janjua for the review of the English of this manuscript. This work was supported by a Grant-in-aid for Scientific Research from the Ministry of Education, Science and Culture of Japan.",
year = "1994",
month = jun,
day = "20",
doi = "10.1016/0006-8993(94)91138-X",
language = "English",
volume = "648",
pages = "337--341",
journal = "Molecular Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",
}