Immunosuppressive effect of restraint stress on the initiation of allergic rhinitis in mice

Keiko Nishioka, Mitsuhiro Okano, Yumiko Ichihara, Naoto Ichihara, Kazunori Nishizaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Exposure to acute stressors modulates both innate and acquired immune function. However, little is known about whether stress has the potential to modulate the pathogenesis of allergic rhinitis. Objectives: To determine the effects of acute restraint stress on the initiation of allergic rhinitis in a murine model. Methods: CBA/J mice were repeatedly intranasally sensitized with phospholipase A2 (PLA2) from honeybee venom without adjuvant. Restraint stress was applied using uniform cylinders once a week for a continuous 8-hour period, on five occasions in total. Production of PLA2-specific antibodies and degree of nasal and blood eosinophilia were compared between stressed and control mice. Results: Repeated intranasal sensitization with PLA2 induced PLA2-specific IgE and marked eosinophilia in both the nose and blood in CBA/J mice. Exposure to restraint stress significantly inhibited production of PLA2-specific IgE, IgG1 and IgG2a. Conversely, the stress exerted no significant effect on eosinophilia. Conclusions: Exposure to acute restraint stress inhibits antigen-specific antibody production, but not local or systemic eosinophilia. The results of this study suggest that acute stress has the potential to modulate the initiation of allergic rhinitis.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalInternational Archives of Allergy and Immunology
Volume136
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Phospholipases A2
Immunosuppressive Agents
Eosinophilia
Inbred CBA Mouse
Nose
Immunoglobulin E
Venoms
Antibody Formation
Immunoglobulin G
Allergic Rhinitis
Antigens
Antibodies

Keywords

  • Allergic rhinitis
  • IgE
  • IgG1
  • IgG2a
  • Immunosuppression
  • Mouse model
  • Nasal sensitization
  • Phospholipase A2
  • Restraint stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Immunosuppressive effect of restraint stress on the initiation of allergic rhinitis in mice. / Nishioka, Keiko; Okano, Mitsuhiro; Ichihara, Yumiko; Ichihara, Naoto; Nishizaki, Kazunori.

In: International Archives of Allergy and Immunology, Vol. 136, No. 2, 02.2005, p. 142-147.

Research output: Contribution to journalArticle

Nishioka, Keiko ; Okano, Mitsuhiro ; Ichihara, Yumiko ; Ichihara, Naoto ; Nishizaki, Kazunori. / Immunosuppressive effect of restraint stress on the initiation of allergic rhinitis in mice. In: International Archives of Allergy and Immunology. 2005 ; Vol. 136, No. 2. pp. 142-147.
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