Immunosuppression for islet transplantation

Hirofumi Noguchi, Shinichi Matsumoto, Masayuki Matsushita, Naoya Kobayashi, Koichi Tanaka, Hideki Matsui, Noriaki Tanaka

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

The development by the Edmonton group of a sirolimus-based, steroid-free, low-tacrolimus regimen is a significant breakthrough that allows the rate of insulin independence after islet transplantation to increase from 13% to 80% at 1 year; however, the rate is reduced to 50% at 3 years, attributed to prolonged tacrolimus exposure. Recently, immunosuppression agents such as cyclosporine, mycophenolate mofetil, and the novel agent FTY 720 have been used instead of tacrolimus. Lymphocytedepleting antibodies such as anti-thymocyte globulin, alemtuzumab, and hOKT3γ1 (ala, ala) have been launched, and a costimulatory blockade of anti-CD40 monoclonal antibodies and CTLA4-Ig will be attempted in the near future. Moreover, the potential of a novel immunosuppressing peptide could now be realized using new technology called the protein transduction system. In this review, we show some of the most recent contributions to the advancement of knowledge in this field. Copyright

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalActa medica Okayama
Volume60
Issue number2
Publication statusPublished - Apr 2006

Keywords

  • Edmonton protocol
  • Islet transplantation
  • Protein transduction system
  • Steroid-free

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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