Immunosuppressant FK506 prevents messy fiber sprouting induced by kindling stimulation

Akiyoshi Moriwaki; Yun Fei Lu; Yasushi Hayashi; Kazuhito Tomizawa; Masaaki Tokuda; Toshifumi Itano; Osamu Hatase; Hideki Matsui

doi:10.1016/S0168-0102(96)01036-X

Immunosuppressant FK506 prevents messy fiber sprouting induced by kindling stimulation

Akiyoshi Moriwaki, Yun Fei Lu, Yasushi Hayashi, Kazuhito Tomizawa, Masaaki Tokuda, Toshifumi Itano, Osamu Hatase, Hideki Matsui

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Kindling stimulation induces expansive growth of the axons of the dentate granule cells, the mossy fiber, into several areas of the hippocampus. An intraperitoneal injection of the immunosuppressant drug FK506, which is a specific inhibitor of Ca²⁺-calmodulin dependent phosphatase, calcineurin, prevented the full development of kindling as well as mossy fiber sprouting. The results show a correlation between mossy fiber sprouting and the development of kindling. The results suggest also that calcineurin may have a promoting role in mossy fiber sprouting and subsequent synaptogenesis.

Original language	English
Pages (from-to)	191-194
Number of pages	4
Journal	Neuroscience Research
Volume	25
Issue number	2
DOIs	https://doi.org/10.1016/S0168-0102(96)01036-X
Publication status	Published - Jun 1996

Keywords

Calcineurin
FK506
Kindling
Mossy fiber
Phosphatase
Sprouting
Timm histochemistry

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/S0168-0102(96)01036-X

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title = "Immunosuppressant FK506 prevents messy fiber sprouting induced by kindling stimulation",

abstract = "Kindling stimulation induces expansive growth of the axons of the dentate granule cells, the mossy fiber, into several areas of the hippocampus. An intraperitoneal injection of the immunosuppressant drug FK506, which is a specific inhibitor of Ca2+-calmodulin dependent phosphatase, calcineurin, prevented the full development of kindling as well as mossy fiber sprouting. The results show a correlation between mossy fiber sprouting and the development of kindling. The results suggest also that calcineurin may have a promoting role in mossy fiber sprouting and subsequent synaptogenesis.",

keywords = "Calcineurin, FK506, Kindling, Mossy fiber, Phosphatase, Sprouting, Timm histochemistry",

author = "Akiyoshi Moriwaki and Lu, {Yun Fei} and Yasushi Hayashi and Kazuhito Tomizawa and Masaaki Tokuda and Toshifumi Itano and Osamu Hatase and Hideki Matsui",

year = "1996",

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AU - Moriwaki, Akiyoshi

AU - Lu, Yun Fei

AU - Hayashi, Yasushi

AU - Tomizawa, Kazuhito

AU - Tokuda, Masaaki

AU - Itano, Toshifumi

AU - Hatase, Osamu

AU - Matsui, Hideki

PY - 1996/6

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AB - Kindling stimulation induces expansive growth of the axons of the dentate granule cells, the mossy fiber, into several areas of the hippocampus. An intraperitoneal injection of the immunosuppressant drug FK506, which is a specific inhibitor of Ca2+-calmodulin dependent phosphatase, calcineurin, prevented the full development of kindling as well as mossy fiber sprouting. The results show a correlation between mossy fiber sprouting and the development of kindling. The results suggest also that calcineurin may have a promoting role in mossy fiber sprouting and subsequent synaptogenesis.

KW - Calcineurin

KW - FK506

KW - Kindling

KW - Mossy fiber

KW - Phosphatase

KW - Sprouting

KW - Timm histochemistry

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