Abstract
The purpose of this study was to determine the association between β2-glycoprotein I (β2GPI)-dependent anticardiolipin antibodies (aCL) and β2GPI-independent aCL and their respective relevance to adverse pregnancy outcomes. Therefore, we prospectively studied 210 normal pregnant women, utilizing a modified enzyme-linked immunosorbent assay method for β2GPI-dependent and -independent aCL. Seven of the 210 pregnant women (3.3%) demonstrated evidence for β2GPI-independent immunoglobulin G (IgG)-aCL. Two patients, who also appeared positive for β2GPI-dependent IgG-aCL, were proven to be false positives. Amongst the 210 patients, not one was thus positive for β2GPI-dependent aCL. Women with β2GPI-independent aCL demonstrated no adverse pregnancy outcomes. These results suggest that the presence of β2GPI-independent aCL is not associated with the presence of β2GPI-dependent aCL, though it may give rise to false positive results. Since the presence of β2GPI-independent aCL does not appear to be associated with adverse pregnancy outcomes, β2GPI-dependent assays may represent better markers of miscarriage risk.
Original language | English |
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Pages (from-to) | 1849-1851 |
Number of pages | 3 |
Journal | Human Reproduction |
Volume | 9 |
Issue number | 10 |
DOIs | |
Publication status | Published - Oct 1994 |
Externally published | Yes |
Keywords
- Anticardiolipin antibodies
- Pregnancy
- β2-glycoprotein I
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynaecology