Immunology: β2-glycoprotein i-dependent and -independent anticardiolipin antibodies in healthy pregnant women

K. Aoki, E. Matsuura, H. Sasa, Y. Yagami, A. B. Dudkiewicz, N. Gleicher

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The purpose of this study was to determine the association between β2-glycoprotein I (β2GPI)-dependent anticardiolipin antibodies (aCL) and β2GPI-independent aCL and their respective relevance to adverse pregnancy outcomes. Therefore, we prospectively studied 210 normal pregnant women, utilizing a modified enzyme-linked immunosorbent assay method for β2GPI-dependent and -independent aCL. Seven of the 210 pregnant women (3.3%) demonstrated evidence for β2GPI-independent immunoglobulin G (IgG)-aCL. Two patients, who also appeared positive for β2GPI-dependent IgG-aCL, were proven to be false positives. Amongst the 210 patients, not one was thus positive for β2GPI-dependent aCL. Women with β2GPI-independent aCL demonstrated no adverse pregnancy outcomes. These results suggest that the presence of β2GPI-independent aCL is not associated with the presence of β2GPI-dependent aCL, though it may give rise to false positive results. Since the presence of β2GPI-independent aCL does not appear to be associated with adverse pregnancy outcomes, β2GPI-dependent assays may represent better markers of miscarriage risk.

Original languageEnglish
Pages (from-to)1849-1851
Number of pages3
JournalHuman Reproduction
Issue number10
Publication statusPublished - Oct 1994
Externally publishedYes


  • Anticardiolipin antibodies
  • Pregnancy
  • β2-glycoprotein I

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology


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