Immunological effects of silica and asbestos.

Takemi Otsuki, Megumi Maeda, Shuko Murakami, Hiroaki Hayashi, Yoshie Miura, Masayasu Kusaka, Takashi Nakano, Kazuya Fukuoka, Takumi Kishimoto, Fuminori Hyodoh, Ayako Ueki, Yasumitsu Nishimura

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Silicosis patients (SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular, SIL sometimes complicates autoimmune diseases such as systemic scleroderma, rheumatoid arthritis (known as Caplan syndrome), and systemic lupus erythematoses. In addition, malignant complications such as lung cancer and malignant mesothelioma often occur in patients exposed to asbestos, and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica, more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors, respectively. In addition, immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies, various cytokines, and molecule-targeting therapies. In particular, as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan, efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety.

Original languageEnglish
Pages (from-to)261-268
Number of pages8
JournalCellular & molecular immunology
Volume4
Issue number4
Publication statusPublished - Aug 2007
Externally publishedYes

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Asbestos
Silicon Dioxide
Silicosis
Neoplasms
Autoimmunity
Caplan Syndrome
Immunity
Systemic Scleroderma
Social Problems
Cell- and Tissue-Based Therapy
Autoimmune Diseases
Lung Neoplasms
Rheumatoid Arthritis
Japan
Anxiety
Cytokines
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Otsuki, T., Maeda, M., Murakami, S., Hayashi, H., Miura, Y., Kusaka, M., ... Nishimura, Y. (2007). Immunological effects of silica and asbestos. Cellular & molecular immunology, 4(4), 261-268.

Immunological effects of silica and asbestos. / Otsuki, Takemi; Maeda, Megumi; Murakami, Shuko; Hayashi, Hiroaki; Miura, Yoshie; Kusaka, Masayasu; Nakano, Takashi; Fukuoka, Kazuya; Kishimoto, Takumi; Hyodoh, Fuminori; Ueki, Ayako; Nishimura, Yasumitsu.

In: Cellular & molecular immunology, Vol. 4, No. 4, 08.2007, p. 261-268.

Research output: Contribution to journalArticle

Otsuki, T, Maeda, M, Murakami, S, Hayashi, H, Miura, Y, Kusaka, M, Nakano, T, Fukuoka, K, Kishimoto, T, Hyodoh, F, Ueki, A & Nishimura, Y 2007, 'Immunological effects of silica and asbestos.', Cellular & molecular immunology, vol. 4, no. 4, pp. 261-268.
Otsuki T, Maeda M, Murakami S, Hayashi H, Miura Y, Kusaka M et al. Immunological effects of silica and asbestos. Cellular & molecular immunology. 2007 Aug;4(4):261-268.
Otsuki, Takemi ; Maeda, Megumi ; Murakami, Shuko ; Hayashi, Hiroaki ; Miura, Yoshie ; Kusaka, Masayasu ; Nakano, Takashi ; Fukuoka, Kazuya ; Kishimoto, Takumi ; Hyodoh, Fuminori ; Ueki, Ayako ; Nishimura, Yasumitsu. / Immunological effects of silica and asbestos. In: Cellular & molecular immunology. 2007 ; Vol. 4, No. 4. pp. 261-268.
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