IMMUNOLOCALIZATION of INHIBIN/ACTIVIN SUBUNITS and STEROIDOGENIC ENZYMES in the TESTES of AN ADULT AFRICAN ELEPHANT (LOXODONTA AFRICANA)

Qinglin Li, Lu Lu, Qiang Weng, Shig Kawakami, Eriko Saito, Tatsuya Yamamoto, Yuki Yamamoto, Saroch Kaewmanee, Kentaro Nagaoka, Gen Watanabe, Kazuyoshi Taya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this case report, the authors investigated immunolocalization of inhibin α and inhibin/activin βA and βB subunits, as well as steroidogenic enzymes, in the testes of an African elephant. Testes were collected from a reproductively active male African elephant (24 yr old) at autopsy. Histologically, all types of spermatogenic cells including mature-phase spermatozoa were found in the seminiferous tubules. Positive immunostaining for inhibin α and inhibin/activin βA and βB subunits was observed in Sertoli and Leydig cells. In addition, P450scc, 3βHSD, P450c17, and P450arom were also detected in the cytoplasm of Leydig cells. These results suggested that Leydig cells of adult African elephant testes have the ability to synthesize progestin, androgen, and estrogen, whereas both Sertoli and Leydig cells appear as a major source of inhibin secretion in the male African elephant.

Original languageEnglish
Pages (from-to)419-422
Number of pages4
JournalJournal of Zoo and Wildlife Medicine
Volume47
Issue number2
DOIs
Publication statusPublished - Jun 1 2016

Fingerprint

inhibin
Loxodonta africana
Leydig Cells
Leydig cells
Inhibins
Testis
Sertoli Cells
activins
testes
Sertoli cells
Seminiferous Tubules
Progestins
seminiferous tubules
Androgens
progestational hormones
Spermatozoa
Autopsy
protein subunits
Estrogens
Cytoplasm

Keywords

  • African elephant
  • immunohistochmestry
  • inhibin
  • steroidogenic enzyme
  • testis.

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

IMMUNOLOCALIZATION of INHIBIN/ACTIVIN SUBUNITS and STEROIDOGENIC ENZYMES in the TESTES of AN ADULT AFRICAN ELEPHANT (LOXODONTA AFRICANA). / Li, Qinglin; Lu, Lu; Weng, Qiang; Kawakami, Shig; Saito, Eriko; Yamamoto, Tatsuya; Yamamoto, Yuki; Kaewmanee, Saroch; Nagaoka, Kentaro; Watanabe, Gen; Taya, Kazuyoshi.

In: Journal of Zoo and Wildlife Medicine, Vol. 47, No. 2, 01.06.2016, p. 419-422.

Research output: Contribution to journalArticle

Li, Q, Lu, L, Weng, Q, Kawakami, S, Saito, E, Yamamoto, T, Yamamoto, Y, Kaewmanee, S, Nagaoka, K, Watanabe, G & Taya, K 2016, 'IMMUNOLOCALIZATION of INHIBIN/ACTIVIN SUBUNITS and STEROIDOGENIC ENZYMES in the TESTES of AN ADULT AFRICAN ELEPHANT (LOXODONTA AFRICANA)', Journal of Zoo and Wildlife Medicine, vol. 47, no. 2, pp. 419-422. https://doi.org/10.1638/2015-0091.1
Li, Qinglin ; Lu, Lu ; Weng, Qiang ; Kawakami, Shig ; Saito, Eriko ; Yamamoto, Tatsuya ; Yamamoto, Yuki ; Kaewmanee, Saroch ; Nagaoka, Kentaro ; Watanabe, Gen ; Taya, Kazuyoshi. / IMMUNOLOCALIZATION of INHIBIN/ACTIVIN SUBUNITS and STEROIDOGENIC ENZYMES in the TESTES of AN ADULT AFRICAN ELEPHANT (LOXODONTA AFRICANA). In: Journal of Zoo and Wildlife Medicine. 2016 ; Vol. 47, No. 2. pp. 419-422.
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