Immunohistochemistry of Vasohibin-2 in Human Kidney Disease: Implications in Impaired Glucose Tolerance and Reduced Renal Function

Yuka Arata, Katsuyuki Tanabe, Norikazu Hinamoto, Hiroko Yamasaki, Hitoshi Sugiyama, Yohei Maeshima, Naoki Kanomata, Yasufumi Sato, Jun Wada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Several angiogenesis-related factors are known to play important roles in the pathogenesis of kidney disease. Vasohibin-2 (VASH-2) was recently reported as a novel proangiogenic factor. Although VASH-2 was demonstrated to accelerate tumor angiogenesis, its roles in non-tumor processes including renal disease have not been well elucidated yet. Here, we performed a retrospective study including an immunohistochemical analysis of human kidney biopsy specimens from 82 Japanese patients with a variety of kidney diseases, and we evaluated the correlations between the immunoreactivity of VASH-2 and the patients' clinicopathological parameters. VASH-2 immunoreactivity was detected in varying degrees in renal tubules as well as in peritubular capillaries and vasa recta. The cortical and medullary tubule VASH-2+ scores were correlated with the presence of hypertension, and the medullary tubule VASH-2+ score was significantly correlated with the blood glucose (p=0.029, r=0.35) and hemoglobin A1c levels (p=0.0066, r=0.39). Moreover, decreased VASH-2+ scores in the vasa recta were associated with reduced renal function (p=0.0003). These results suggest that VASH-2 could play an important role in the pathogenesis of renal diseases, and that VASH-2 is closely associated with hypertension and impaired glucose tolerance.

Original languageEnglish
Pages (from-to)369-380
Number of pages12
JournalActa Medica Okayama
Volume71
Issue number5
DOIs
Publication statusPublished - Oct 1 2017

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Glucose Intolerance
Kidney Diseases
Immunohistochemistry
Kidney
Glucose
Rectum
Biopsy
Hypertension
Angiogenesis Inducing Agents
Blood Glucose
Tumors
Hemoglobins
Retrospective Studies
human VASH2 protein
Neoplasms

Keywords

  • kidney disease
  • medullary tubules
  • vasa recta
  • vasohibin-2

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Immunohistochemistry of Vasohibin-2 in Human Kidney Disease : Implications in Impaired Glucose Tolerance and Reduced Renal Function. / Arata, Yuka; Tanabe, Katsuyuki; Hinamoto, Norikazu; Yamasaki, Hiroko; Sugiyama, Hitoshi; Maeshima, Yohei; Kanomata, Naoki; Sato, Yasufumi; Wada, Jun.

In: Acta Medica Okayama, Vol. 71, No. 5, 01.10.2017, p. 369-380.

Research output: Contribution to journalArticle

Arata, Yuka ; Tanabe, Katsuyuki ; Hinamoto, Norikazu ; Yamasaki, Hiroko ; Sugiyama, Hitoshi ; Maeshima, Yohei ; Kanomata, Naoki ; Sato, Yasufumi ; Wada, Jun. / Immunohistochemistry of Vasohibin-2 in Human Kidney Disease : Implications in Impaired Glucose Tolerance and Reduced Renal Function. In: Acta Medica Okayama. 2017 ; Vol. 71, No. 5. pp. 369-380.
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