Immunohistochemical study on leukocyte adhesion molecules expressed on lymphatic endothelium

Yoshihiko Sawa, Yuji Yamaoka, Noriyuki Ebata, Yuichi Ashikaga, Takenori Kim, Masatsugu Suzuki, Shigemitsu Yoshida

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Leukocyte adhesion molecules expressed on the lymphatic endothelium in human small intestine and submandibular lymph node were studied immunohistochemically. Lymphatic capillaries in the lamina propria, mucosal muscle layer, and submucosal connective tissue of the intestine and in the capsule of the lymph node showed strong expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1). A few lymphatic capillaries that weakly expressed intercellular adhesion molecule-1 (ICAM-1) were found in the capsule of the lymph node but in the small intestine, no lymphatic capillaries expressed detectable amounts of ICAM-1. Lymphatic capillaries also did not express detectable amounts of endothelial cell-selectin in the small intestine and lymph node. When lymphocytes migrate from tissue into lymphatic capillaries, multiple adhesion molecules may not be required for the migration. PECAM-1, however, may contribute to adherence of lymphocytes to lymphatic endothelium and the expression of adhesion molecules on lymphatic endothelium may be different between tissues.

Original languageEnglish
Pages (from-to)292-297
Number of pages6
JournalMicrovascular Research
Volume57
Issue number3
DOIs
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Lymphatic Endothelium
Lymphatic Vessels
Cell Adhesion Molecules
CD31 Antigens
Lymphocytes
Intercellular Adhesion Molecule-1
Tissue
Lymph Nodes
Capsules
Small Intestine
Adhesion
Selectins
Molecules
Endothelial cells
Muscle
Connective Tissue
Intestines
Mucous Membrane
Endothelial Cells
Muscles

Keywords

  • ICAM-1
  • Lymph node
  • Lymphatic capillary
  • PECAM-1
  • Small intestine

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

Cite this

Immunohistochemical study on leukocyte adhesion molecules expressed on lymphatic endothelium. / Sawa, Yoshihiko; Yamaoka, Yuji; Ebata, Noriyuki; Ashikaga, Yuichi; Kim, Takenori; Suzuki, Masatsugu; Yoshida, Shigemitsu.

In: Microvascular Research, Vol. 57, No. 3, 1999, p. 292-297.

Research output: Contribution to journalArticle

Sawa, Y, Yamaoka, Y, Ebata, N, Ashikaga, Y, Kim, T, Suzuki, M & Yoshida, S 1999, 'Immunohistochemical study on leukocyte adhesion molecules expressed on lymphatic endothelium', Microvascular Research, vol. 57, no. 3, pp. 292-297. https://doi.org/10.1006/mvre.1998.2137
Sawa, Yoshihiko ; Yamaoka, Yuji ; Ebata, Noriyuki ; Ashikaga, Yuichi ; Kim, Takenori ; Suzuki, Masatsugu ; Yoshida, Shigemitsu. / Immunohistochemical study on leukocyte adhesion molecules expressed on lymphatic endothelium. In: Microvascular Research. 1999 ; Vol. 57, No. 3. pp. 292-297.
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