Immunohistochemical studies on human brain tumors using anti-Leu 7 monoclonal antibody in paraffin-embedded specimens

M. Motoi, T. Yoshino, K. Hayashi, S. Nose, Y. Horie, K. Ogawa

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Using the four-step peroxidase-antiper-oxidase (PAP) method, the presence of the antigen recognized with anti-Leu 7 monoclonal antibody was investigated in paraffin-embedded human brain tissue and tumors. The antigen was demonstrated in the myelin sheaths, oligodendrocytes, and some choroid plexus cells in normal brain and in oligodendrogliomas, some astrocytomas and choroid plexus papillomas. The technique can be used to identify hormal and neoplastic oligodendrocytes.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalActa neuropathologica
Issue number1
Publication statusPublished - Mar 1 1985



  • Anti-Leu 7
  • Four-step PAP method
  • Oligodendroglioma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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