Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation

Atsunori Nakao, Hiromi Iwagaki, Tadashi Yosnino, Atsushi Jikuhara, Taiichiro Kanagawa, Toshikazu Kimura, Nagahide Matsubara, Hiroshi Isozaki, Norihisa Takakura, Noriaki Tanaka

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Radiation therapy is believed to be a predisposing factor in the development of carcinoma. During the period from 1974 to 1997, we treated five colorectal cancers in four patients who had undergone pelvic irradiation for cervical cancer. Radiation-induced changes in the remaining bowel were recognized in all of these patients. Of the five tumors, two were histologically diagnosed as mucinous adenocarcinoma, demonstrating a higher distribution than usual: To clarify the characteristics of the tumors, we examined the frequency of mutation in K-ras and p53 genes, and the proliferating cell nuclear antigen (PCNA) proliferation activity. The K-ras and PCNA stains did not show any clear characteristics of radiation-induced colorectal cancers in comparison with ordinary colorectal cancers; however, it was of interest that strongly positive staining was observed in our mucinous adenocarcinomas, even though a low frequency of p53 gene mutation has been reported in ordinary mucinous adenocarcinomas.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalSurgery today
Issue number2
Publication statusPublished - Jan 1 2000


  • Colorectal cancer
  • K-ras
  • Proliferating cell nuclear antigen
  • Radiation
  • p53

ASJC Scopus subject areas

  • Surgery


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