TY - JOUR
T1 - Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation
AU - Nakao, Atsunori
AU - Iwagaki, Hiromi
AU - Yosnino, Tadashi
AU - Jikuhara, Atsushi
AU - Kanagawa, Taiichiro
AU - Kimura, Toshikazu
AU - Matsubara, Nagahide
AU - Isozaki, Hiroshi
AU - Takakura, Norihisa
AU - Tanaka, Noriaki
PY - 2000/1/1
Y1 - 2000/1/1
N2 - Radiation therapy is believed to be a predisposing factor in the development of carcinoma. During the period from 1974 to 1997, we treated five colorectal cancers in four patients who had undergone pelvic irradiation for cervical cancer. Radiation-induced changes in the remaining bowel were recognized in all of these patients. Of the five tumors, two were histologically diagnosed as mucinous adenocarcinoma, demonstrating a higher distribution than usual: To clarify the characteristics of the tumors, we examined the frequency of mutation in K-ras and p53 genes, and the proliferating cell nuclear antigen (PCNA) proliferation activity. The K-ras and PCNA stains did not show any clear characteristics of radiation-induced colorectal cancers in comparison with ordinary colorectal cancers; however, it was of interest that strongly positive staining was observed in our mucinous adenocarcinomas, even though a low frequency of p53 gene mutation has been reported in ordinary mucinous adenocarcinomas.
AB - Radiation therapy is believed to be a predisposing factor in the development of carcinoma. During the period from 1974 to 1997, we treated five colorectal cancers in four patients who had undergone pelvic irradiation for cervical cancer. Radiation-induced changes in the remaining bowel were recognized in all of these patients. Of the five tumors, two were histologically diagnosed as mucinous adenocarcinoma, demonstrating a higher distribution than usual: To clarify the characteristics of the tumors, we examined the frequency of mutation in K-ras and p53 genes, and the proliferating cell nuclear antigen (PCNA) proliferation activity. The K-ras and PCNA stains did not show any clear characteristics of radiation-induced colorectal cancers in comparison with ordinary colorectal cancers; however, it was of interest that strongly positive staining was observed in our mucinous adenocarcinomas, even though a low frequency of p53 gene mutation has been reported in ordinary mucinous adenocarcinomas.
KW - Colorectal cancer
KW - K-ras
KW - Proliferating cell nuclear antigen
KW - Radiation
KW - p53
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U2 - 10.1007/s005950050026
DO - 10.1007/s005950050026
M3 - Article
C2 - 10664332
AN - SCOPUS:0034049682
VL - 30
SP - 117
EP - 121
JO - Japanese Journal of Surgery
JF - Japanese Journal of Surgery
SN - 0941-1291
IS - 2
ER -