Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation

Atsunori Nakao, Hiromi Iwagaki, Tadashi Yoshino, Atsushi Jikuhara, Taiichiro Kanagawa, Toshikazu Kimura, Nagahide Matsubara, Hiroshi Isozaki, Norihisa Takakura, Noriaki Tanaka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Radiation therapy is believed to be a predisposing factor in the development of carcinoma. During the period from 1974 to 1997, we treated five colorectal cancers in four patients who had undergone pelvic irradiation for cervical cancer. Radiation-induced changes in the remaining bowel were recognized in all of these patients. Of the five tumors, two were histologically diagnosed as mucinous adenocarcinoma, demonstrating a higher distribution than usual: To clarify the characteristics of the tumors, we examined the frequency of mutation in K-ras and p53 genes, and the proliferating cell nuclear antigen (PCNA) proliferation activity. The K-ras and PCNA stains did not show any clear characteristics of radiation-induced colorectal cancers in comparison with ordinary colorectal cancers; however, it was of interest that strongly positive staining was observed in our mucinous adenocarcinomas, even though a low frequency of p53 gene mutation has been reported in ordinary mucinous adenocarcinomas.

Original languageEnglish
Pages (from-to)117-121
Number of pages5
JournalSurgery Today
Volume30
Issue number2
Publication statusPublished - 2000

Fingerprint

Mucinous Adenocarcinoma
Colorectal Neoplasms
p53 Genes
Proliferating Cell Nuclear Antigen
Radiation-Induced Neoplasms
ras Genes
Mutation Rate
Uterine Cervical Neoplasms
Causality
Neoplasms
Coloring Agents
Radiotherapy
Radiation
Staining and Labeling
Carcinoma
Mutation

Keywords

  • Colorectal cancer
  • K-ras
  • p53
  • Proliferating cell nuclear antigen
  • Radiation

ASJC Scopus subject areas

  • Surgery

Cite this

Nakao, A., Iwagaki, H., Yoshino, T., Jikuhara, A., Kanagawa, T., Kimura, T., ... Tanaka, N. (2000). Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation. Surgery Today, 30(2), 117-121.

Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation. / Nakao, Atsunori; Iwagaki, Hiromi; Yoshino, Tadashi; Jikuhara, Atsushi; Kanagawa, Taiichiro; Kimura, Toshikazu; Matsubara, Nagahide; Isozaki, Hiroshi; Takakura, Norihisa; Tanaka, Noriaki.

In: Surgery Today, Vol. 30, No. 2, 2000, p. 117-121.

Research output: Contribution to journalArticle

Nakao, A, Iwagaki, H, Yoshino, T, Jikuhara, A, Kanagawa, T, Kimura, T, Matsubara, N, Isozaki, H, Takakura, N & Tanaka, N 2000, 'Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation', Surgery Today, vol. 30, no. 2, pp. 117-121.
Nakao, Atsunori ; Iwagaki, Hiromi ; Yoshino, Tadashi ; Jikuhara, Atsushi ; Kanagawa, Taiichiro ; Kimura, Toshikazu ; Matsubara, Nagahide ; Isozaki, Hiroshi ; Takakura, Norihisa ; Tanaka, Noriaki. / Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation. In: Surgery Today. 2000 ; Vol. 30, No. 2. pp. 117-121.
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