Abstract
The purpose of this study was the immunohistochemical localization and distribution of HNP-1 in the submandibular glands of patients with oral carcinomas. Tissue sections were embedded in paraffin, and HNP-1 was immunostained by the streptavidin-biotin coupled peroxidase method. Striated duct cells in the submandibular glands were stained with anti-defensin antibody. Neutrophils and capillary intimal cells were also stained. Defensins (HNP(s)) are peptides that occur in neutrophils and protect against bacteria and tumor cells. Human α-defensin-1 (HNP-1) is such a peptide, possessing both antimicrobial and cytotoxic activities. The presence of HNP-1 in striated duct cells in the submandibular glands of oral cancer patients, suggests a likely role in tumor immunity, for this peptide.
| Original language | English |
|---|---|
| Pages (from-to) | 1125-1127 |
| Number of pages | 3 |
| Journal | Anticancer Research |
| Volume | 20 |
| Issue number | 2 B |
| Publication status | Published - 2000 |
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Keywords
- Defensin
- HNP-1
- Oral carcinoma
- Striated duct cells
- Submandibular gland
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Immunohistochemical staining of human α-defensin-1 (HNP-1), in the submandibular glands of patients with oral carcinomas. / Mizukawa, Nobuyoshi; Sugiyama, Katsumi; Kamio, Masayuki; Yamachika, Eiki; Ueno, Takaaki; Fukunaga, Joji; Takagi, Shin; Sugahara, Toshio.
In: Anticancer Research, Vol. 20, No. 2 B, 2000, p. 1125-1127.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical staining of human α-defensin-1 (HNP-1), in the submandibular glands of patients with oral carcinomas
AU - Mizukawa, Nobuyoshi
AU - Sugiyama, Katsumi
AU - Kamio, Masayuki
AU - Yamachika, Eiki
AU - Ueno, Takaaki
AU - Fukunaga, Joji
AU - Takagi, Shin
AU - Sugahara, Toshio
PY - 2000
Y1 - 2000
N2 - The purpose of this study was the immunohistochemical localization and distribution of HNP-1 in the submandibular glands of patients with oral carcinomas. Tissue sections were embedded in paraffin, and HNP-1 was immunostained by the streptavidin-biotin coupled peroxidase method. Striated duct cells in the submandibular glands were stained with anti-defensin antibody. Neutrophils and capillary intimal cells were also stained. Defensins (HNP(s)) are peptides that occur in neutrophils and protect against bacteria and tumor cells. Human α-defensin-1 (HNP-1) is such a peptide, possessing both antimicrobial and cytotoxic activities. The presence of HNP-1 in striated duct cells in the submandibular glands of oral cancer patients, suggests a likely role in tumor immunity, for this peptide.
AB - The purpose of this study was the immunohistochemical localization and distribution of HNP-1 in the submandibular glands of patients with oral carcinomas. Tissue sections were embedded in paraffin, and HNP-1 was immunostained by the streptavidin-biotin coupled peroxidase method. Striated duct cells in the submandibular glands were stained with anti-defensin antibody. Neutrophils and capillary intimal cells were also stained. Defensins (HNP(s)) are peptides that occur in neutrophils and protect against bacteria and tumor cells. Human α-defensin-1 (HNP-1) is such a peptide, possessing both antimicrobial and cytotoxic activities. The presence of HNP-1 in striated duct cells in the submandibular glands of oral cancer patients, suggests a likely role in tumor immunity, for this peptide.
KW - Defensin
KW - HNP-1
KW - Oral carcinoma
KW - Striated duct cells
KW - Submandibular gland
UR - http://www.scopus.com/inward/record.url?scp=0034056108&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034056108&partnerID=8YFLogxK
M3 - Article
C2 - 10810407
AN - SCOPUS:0034056108
VL - 20
SP - 1125
EP - 1127
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 2 B
ER -