Abstract
The purpose of this study was the immunohistochemical localization and distribution of HNP-1 in the submandibular glands of patients with oral carcinomas. Tissue sections were embedded in paraffin, and HNP-1 was immunostained by the streptavidin-biotin coupled peroxidase method. Striated duct cells in the submandibular glands were stained with anti-defensin antibody. Neutrophils and capillary intimal cells were also stained. Defensins (HNP(s)) are peptides that occur in neutrophils and protect against bacteria and tumor cells. Human α-defensin-1 (HNP-1) is such a peptide, possessing both antimicrobial and cytotoxic activities. The presence of HNP-1 in striated duct cells in the submandibular glands of oral cancer patients, suggests a likely role in tumor immunity, for this peptide.
| Original language | English |
|---|---|
| Pages (from-to) | 1125-1127 |
| Number of pages | 3 |
| Journal | Anticancer research |
| Volume | 20 |
| Issue number | 2 B |
| Publication status | Published - 2000 |
Keywords
- Defensin
- HNP-1
- Oral carcinoma
- Striated duct cells
- Submandibular gland
ASJC Scopus subject areas
- Oncology
- Cancer Research