Immunohistochemical staining of human α-defensin-1 (HNP-1), in the submandibular glands of patients with oral carcinomas

Nobuyoshi Mizukawa, Katsumi Sugiyama, Masayuki Kamio, Eiki Yamachika, Takaaki Ueno, Joji Fukunaga, Shin Takagi, Toshio Sugahara

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The purpose of this study was the immunohistochemical localization and distribution of HNP-1 in the submandibular glands of patients with oral carcinomas. Tissue sections were embedded in paraffin, and HNP-1 was immunostained by the streptavidin-biotin coupled peroxidase method. Striated duct cells in the submandibular glands were stained with anti-defensin antibody. Neutrophils and capillary intimal cells were also stained. Defensins (HNP(s)) are peptides that occur in neutrophils and protect against bacteria and tumor cells. Human α-defensin-1 (HNP-1) is such a peptide, possessing both antimicrobial and cytotoxic activities. The presence of HNP-1 in striated duct cells in the submandibular glands of oral cancer patients, suggests a likely role in tumor immunity, for this peptide.

Original languageEnglish
Pages (from-to)1125-1127
Number of pages3
JournalAnticancer research
Volume20
Issue number2 B
Publication statusPublished - 2000

Keywords

  • Defensin
  • HNP-1
  • Oral carcinoma
  • Striated duct cells
  • Submandibular gland

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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