Immunohistochemical localization of notch signaling molecules in ameloblastomas

E. Muraki, K. Nakano, H. Maeda, M. Takayama, M. Jinno, K. Kubo, W. Yoshida, H. Hasegawa, Toshiyuki Kawakami

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequendy positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.

Original languageEnglish
Pages (from-to)253-257
Number of pages5
JournalEuropean journal of medical research
Issue number6
Publication statusPublished - Jun 21 2011
Externally publishedYes


  • Ameloblastoma
  • Cell differentiation
  • Immunohistochemistry
  • Jagged
  • Notch
  • Notch signaling

ASJC Scopus subject areas

  • Medicine(all)


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