TY - JOUR
T1 - Immunohistochemical localization of notch signaling molecules in ameloblastomas
AU - Muraki, E.
AU - Nakano, K.
AU - Maeda, H.
AU - Takayama, M.
AU - Jinno, M.
AU - Kubo, K.
AU - Yoshida, W.
AU - Hasegawa, H.
AU - Kawakami, Toshiyuki
N1 - Funding Information:
Acknowledgments: this study was supported in part by a grant-in aid for Scientific Research (c) (20592349) from the Japan Society for the Promotion of Science and also supported in part by Matsumoto Dental university Promotion Research grants 2009 and 2010. the authors thank to Professor DM carlson of Matsumoto Dental university for his critical reading of the manuscript.
PY - 2011/6/21
Y1 - 2011/6/21
N2 - We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequendy positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.
AB - We examined Notch signaling molecules, Notch1 and Jagged1, in serial large cases of typical solid/multicystic ameloblastoma. In general, Notch positive staining products were frequently detected in the cytoplasms of the cells. In the same cells, Jagged positive staining were also frequently observed, while only occasionally positive in peripheral cells, especially in cuboidal cells. The results showed that these morphogenesis regulation factors are closely related to cytological differentiation in neoplastic cells of ameloblastoma. The Notch and Jagged positive-cell ratios were frequendy positive, and the ratios were nearly the same between the varied histopathological, cytological patterns. However, the less-differentiated cells were fewer in number than that of well-differentiated cells.
KW - Ameloblastoma
KW - Cell differentiation
KW - Immunohistochemistry
KW - Jagged
KW - Notch
KW - Notch signaling
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U2 - 10.1186/2047-783x-16-6-253
DO - 10.1186/2047-783x-16-6-253
M3 - Article
C2 - 21810559
AN - SCOPUS:79960272686
SN - 0949-2321
VL - 16
SP - 253
EP - 257
JO - European Journal of Medical Research
JF - European Journal of Medical Research
IS - 6
ER -