Immunohistochemical localization of macrophage migration inhibitory factor (MIF) in tanycytes, subcommissural organ and choroid plexus in the rat brain

Masahiro Nishibori, Naoki Nakaya, Shuji Mori, Kiyomi Saeki

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We investigated the immunohistochemical localization of the macrophage migration inhibitory factor (MIF) in the rat brain. In addition to epithelial ependymal cells lining the ventricular wall, tanycytes in the basomedial hypothalamus were heavily immunostained. The immunoreactive processes of tanycytes made contacts to sinusoidal capillaries and reached the pial surface forming an immuno-positive structure at the floor of the hypothalamus. Other immunoreactive cells contained the subcommissural organ in the roof of the third ventricle and the epithelial lamina of the choroid plexus. The localization of MIF in cells which have contact with cerebrospinal fluid and blood vessels suggests that MIF might play a role as a humoral factor in the brain.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalBrain Research
Volume758
Issue number1-2
DOIs
Publication statusPublished - May 30 1997

Keywords

  • Choroid plexus
  • Ependyma
  • Macrophage migration inhibitory factor
  • Subcommissural organ
  • Tanycyte

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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