Immunohistochemical localization of D-aspartate in islets of Langerhans

Miki Hiasa, Yoshinori Moriyama

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.

Original languageEnglish
Pages (from-to)1251-1253
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number6
Publication statusPublished - Jun 2006
Externally publishedYes


  • D-aspartate
  • Insulin
  • Islets of Langerhans
  • α cell
  • β cell

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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