Abstract
D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.
| Original language | English |
|---|---|
| Pages (from-to) | 1251-1253 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2006 |
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Keywords
- α cell
- β cell
- D-aspartate
- Insulin
- Islets of Langerhans
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Immunohistochemical localization of D-aspartate in islets of Langerhans. / Hiasa, Miki; Moriyama, Yoshinori.
In: Biological and Pharmaceutical Bulletin, Vol. 29, No. 6, 06.2006, p. 1251-1253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Immunohistochemical localization of D-aspartate in islets of Langerhans
AU - Hiasa, Miki
AU - Moriyama, Yoshinori
PY - 2006/6
Y1 - 2006/6
N2 - D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.
AB - D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.
KW - α cell
KW - β cell
KW - D-aspartate
KW - Insulin
KW - Islets of Langerhans
UR - http://www.scopus.com/inward/record.url?scp=33744900079&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744900079&partnerID=8YFLogxK
U2 - 10.1248/bpb.29.1251
DO - 10.1248/bpb.29.1251
M3 - Article
C2 - 16755027
AN - SCOPUS:33744900079
VL - 29
SP - 1251
EP - 1253
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 6
ER -