Abstract
D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.
| Original language | English |
|---|---|
| Pages (from-to) | 1251-1253 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2006 |
| Externally published | Yes |
Keywords
- D-aspartate
- Insulin
- Islets of Langerhans
- α cell
- β cell
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
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Cite this
Hiasa, M., & Moriyama, Y. (2006). Immunohistochemical localization of D-aspartate in islets of Langerhans. Biological and Pharmaceutical Bulletin, 29(6), 1251-1253. https://doi.org/10.1248/bpb.29.1251