Immunohistochemical localization of D-aspartate in islets of Langerhans

Miki Hiasa; Yoshinori Moriyama

doi:10.1248/bpb.29.1251

Immunohistochemical localization of D-aspartate in islets of Langerhans

Miki Hiasa, Yoshinori Moriyama

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.

Original language	English
Pages (from-to)	1251-1253
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	29
Issue number	6
DOIs	https://doi.org/10.1248/bpb.29.1251
Publication status	Published - Jun 2006

Keywords

D-aspartate
Insulin
Islets of Langerhans
α cell
β cell

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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AB - D-Aspartate is a putative modulator of neuroendocrine functions, and is present in various neuroendocrine cells as well as the central nervous system. Here we show that the islet of Langerhans is a D-aspartate-containing endocrine organ. Immunohistochemical analysis with specific antibodies against D-aspartate indicated that D-aspartate is present in all islet cells, and predominantly present in a cells and a subpopulation of F-cells. Since these cells are glutamatergic in nature, it is possible that D-aspartate is involved in the glutamate signaling pathways in the islets.

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KW - Insulin

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KW - α cell

KW - β cell

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Immunohistochemical localization of D-aspartate in islets of Langerhans

Abstract

Keywords

ASJC Scopus subject areas

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