Immunohistochemical localization of γ and β subunits of epithelial Na+ channel in the rat molar tooth pulp

H. Ichikawa, T. Fukuda, R. Terayama, T. Yamaai, T. Kuboki, T. Sugimoto

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The distribution of γ and β subunits of epithelial Na + channel (ENaC), markers for low-threshold mechanoreceptors in peripheral tissues, was examined in the tooth pulp. In the root pulp, γENaC- and βENaC-immunoreactive (IR) nerve fibers showed a thick smooth appearance. These nerve fibers ascended toward the pulp horn and formed subodontoblastic nerve plexuses. Immunoelectron microscopic method revealed that 63% of axons were immunoreactive for γENaC in the root pulp. Virtually all myelinated axons showed γENaC-IR (97%), whereas unmyelinated axons were mostly devoid of it (12%). These findings suggest that myelinated tooth pulp nociceptors respond to mechanical stimuli.

Original languageEnglish
Pages (from-to)138-141
Number of pages4
JournalBrain Research
Issue number1-2
Publication statusPublished - Dec 14 2005


  • ENaC
  • Immunohistochemistry
  • Tooth pulp
  • Trigeminal ganglion
  • VRL-1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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