Immunohistochemical detection of P-glycoprotein and carcinoembryonic antigen in small cell lung cancer

with reference to predictability of response to chemotherapy.

Y. Segawa, T. Ohnoshi, S. Hiraki, H. Ueoka, Katsuyuki Kiura, H. Kamei, Masahiro Tabata, T. Shibayama, K. Miyatake, K. Genba

Research output: Contribution to journalArticle

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Abstract

In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalActa Medica Okayama
Volume47
Issue number3
Publication statusPublished - Jun 1993

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Chemotherapy
Carcinoembryonic Antigen
Small Cell Lung Carcinoma
P-Glycoprotein
Tumors
Cells
Drug Therapy
Neoplasms
Recurrence
Salvaging
Neoplasm Antigens
Serum
Disease-Free Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Immunohistochemical detection of P-glycoprotein and carcinoembryonic antigen in small cell lung cancer : with reference to predictability of response to chemotherapy. / Segawa, Y.; Ohnoshi, T.; Hiraki, S.; Ueoka, H.; Kiura, Katsuyuki; Kamei, H.; Tabata, Masahiro; Shibayama, T.; Miyatake, K.; Genba, K.

In: Acta Medica Okayama, Vol. 47, No. 3, 06.1993, p. 181-189.

Research output: Contribution to journalArticle

Segawa, Y. ; Ohnoshi, T. ; Hiraki, S. ; Ueoka, H. ; Kiura, Katsuyuki ; Kamei, H. ; Tabata, Masahiro ; Shibayama, T. ; Miyatake, K. ; Genba, K. / Immunohistochemical detection of P-glycoprotein and carcinoembryonic antigen in small cell lung cancer : with reference to predictability of response to chemotherapy. In: Acta Medica Okayama. 1993 ; Vol. 47, No. 3. pp. 181-189.
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abstract = "In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75{\%} for P-gp-positive initial tumors and 86{\%} for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy.",
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