Immunohistochemical detection of P-glycoprotein and carcinoembryonic antigen in small cell lung cancer: with reference to predictability of response to chemotherapy.

Y. Segawa, T. Ohnoshi, S. Hiraki, H. Ueoka, Katsuyuki Kiura, H. Kamei, Masahiro Tabata, T. Shibayama, K. Miyatake, K. Genba

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Abstract

In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75% for P-gp-positive initial tumors and 86% for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalActa Medica Okayama
Volume47
Issue number3
Publication statusPublished - Jun 1993

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Chemotherapy
Carcinoembryonic Antigen
Small Cell Lung Carcinoma
P-Glycoprotein
Tumors
Cells
Drug Therapy
Neoplasms
Recurrence
Salvaging
Neoplasm Antigens
Serum
Disease-Free Survival

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Immunohistochemical detection of P-glycoprotein and carcinoembryonic antigen in small cell lung cancer : with reference to predictability of response to chemotherapy. / Segawa, Y.; Ohnoshi, T.; Hiraki, S.; Ueoka, H.; Kiura, Katsuyuki; Kamei, H.; Tabata, Masahiro; Shibayama, T.; Miyatake, K.; Genba, K.

In: Acta Medica Okayama, Vol. 47, No. 3, 06.1993, p. 181-189.

Research output: Contribution to journalArticle

Segawa, Y. ; Ohnoshi, T. ; Hiraki, S. ; Ueoka, H. ; Kiura, Katsuyuki ; Kamei, H. ; Tabata, Masahiro ; Shibayama, T. ; Miyatake, K. ; Genba, K. / Immunohistochemical detection of P-glycoprotein and carcinoembryonic antigen in small cell lung cancer : with reference to predictability of response to chemotherapy. In: Acta Medica Okayama. 1993 ; Vol. 47, No. 3. pp. 181-189.
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abstract = "In an attempt to elucidate the tumor properties relating to responsiveness to chemotherapy, we examined immunohistochemically the expression of P-glycoprotein (P-gp) and carcinoembryonic antigen (CEA) in small cell lung cancer (SCLC) tumors. Tumor specimens from 33 patients were obtained at the time of diagnosis and relapse. Four patients expressed P-gp in their initial tumors, and 7 others did in recurrent tumors. The overall response rate to chemotherapy of the initial tumors was 75{\%} for P-gp-positive initial tumors and 86{\%} for P-gp-negative tumors, whereas the disease-free and overall survival times were significantly shorter in the former than the latter. Three patients showed CEA in their initial tumors, and 5 others did in recurrent tumors. The patients with CEA-positive initial tumors tended to relapse earlier than those with CEA-negative tumors. In addition, recurrent tumors expressing CEA were resistant to salvage chemotherapy. A clear correlation between CEA expression by tumors and the CEA level in the serum was observed at diagnosis as well as at relapse. These findings indicate that P-gp and/or CEA expression by a tumor and elevated CEA level in the serum may predict refractoriness of the tumor to chemotherapy.",
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