Immunohistochemical detection of neuroendocrine differentiation in non-small-cell lung cancer and its clinical implications

Yoshihiko Segawa, Saburo Takata, Masanori Fujii, Isao Oze, Yoshiro Fujiwara, Yuka Kato, Atsuko Ogino, Eisaku Komori, Shigeki Sawada, Motohiro Yamashita, Rieko Nishimura, Norihiro Teramoto, Shigemitsu Takashima

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27 Citations (Scopus)

Abstract

Purpose: The purpose of this study was to prospectively assess the clinical implications of neuroendocrine (NE) differentiation in non-small-cell lung cancer (NSCLC) tumors. Methods: This study accrued subjects suspected to have lung cancer who underwent diagnostic bronchoscopy. Bronchoscopically-biopsied specimens were subjected to routine pathologic examination, and immunohistochemical studies were then performed if lung cancer was diagnosed. Chromogranin-A, synaptophysin, neural cell adhesion molecule, and Leu7 were used to demonstrate NE differentiation. Results: A total of 280 subjects were accrued to this study over a period of 2 years. Among them, 149 subjects were assessable for this study, and 130 were diagnosed as having NSCLC tumors (55 adenocarcinomas, 50 squamous cell carcinomas, 24 NSCLCs not otherwise specified, and 1 typical carcinoid). Large cell NE carcinoma was not observed in this study. Immunohistochemically, NE differentiation was detected in 16% of NSCLC tumors excluding typical carcinoid. By status of NE differentiation of NSCLC tumors, progression-free survivals were similar in 73 patients undergoing non-surgical treatment (positive, n = 10; negative, n = 63) and 43 patients undergoing surgical resection (positive, n = 8; negative, n = 35), respectively. Overall survival of patients with NE-positive tumors appeared to be favorable both for those undergoing non-surgical treatment and those undergoing surgical resection, though the differences in survival were not significant (P = 0.11 and 0.35, respectively). Conclusions: NE differentiation was detected in 16% of NSCLC tumors in our study. However, the prognostic implications of the presence of this feature could not be clearly determined in this study.

Original languageEnglish
Pages (from-to)1055-1059
Number of pages5
JournalJournal of cancer research and clinical oncology
Volume135
Issue number8
DOIs
Publication statusPublished - Aug 1 2009

Keywords

  • Immunohistochemistry
  • Neuroendocrine differentiation
  • Neuroendocrine lung tumor
  • Non-small-cell lung carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Segawa, Y., Takata, S., Fujii, M., Oze, I., Fujiwara, Y., Kato, Y., Ogino, A., Komori, E., Sawada, S., Yamashita, M., Nishimura, R., Teramoto, N., & Takashima, S. (2009). Immunohistochemical detection of neuroendocrine differentiation in non-small-cell lung cancer and its clinical implications. Journal of cancer research and clinical oncology, 135(8), 1055-1059. https://doi.org/10.1007/s00432-009-0544-1