Immunohistochemical detection of erythropoietin, platelet-derived growth factor and their receptors in ameloblastomas

Xiaodong Yin, Jiankai Xu, Jinna Shi, Kewen Lv, Eryang Zhao, Tenglong Hu, Ryo Tamamura, Hitoshi Nagatsuka, Xiaohui Jiao

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Ameloblastoma (AB) is the most common odontogenic epithelium-derived tumor, but has unclear etiology. Various ligand/receptor systems are implicated in ameloblastoma development. In this study, we explored the expression of erythropoietin (EPO), platelet-derived growth factor (PDGF) and their receptors (EPOR, PDGFR) in ABs, and the potential origins of ABs from keratocystic odontogenic tumors (KCOTs) and tooth germs in control groups. Immunostaining was performed using antibodies for EPO, EPOR, PDGF-A and PDGFR-ct. Statistical analysis was performed based on immunoreactivity. We found that EPOR expression was significantly higher in ABs than in KCOTs (P

Original languageEnglish
Pages (from-to)19-26
Number of pages8
JournalJournal of Hard Tissue Biology
Volume18
Issue number1
DOIs
Publication statusPublished - 2009

Fingerprint

Odontogenic Tumors
Ameloblastoma
Platelet-Derived Growth Factor Receptors
Erythropoietin
Platelets
Tumors
Tooth Germ
Epithelium
Ligands
Antibodies
Control Groups
Statistical methods
Neoplasms
Intercellular Signaling Peptides and Proteins
platelet-derived growth factor A

Keywords

  • Ameloblastoma
  • Erythropoietin
  • Keratocystic odontogenic tumor
  • Platelet-derived growth factor
  • Tooth germ

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biomaterials
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Dentistry(all)

Cite this

Immunohistochemical detection of erythropoietin, platelet-derived growth factor and their receptors in ameloblastomas. / Yin, Xiaodong; Xu, Jiankai; Shi, Jinna; Lv, Kewen; Zhao, Eryang; Hu, Tenglong; Tamamura, Ryo; Nagatsuka, Hitoshi; Jiao, Xiaohui.

In: Journal of Hard Tissue Biology, Vol. 18, No. 1, 2009, p. 19-26.

Research output: Contribution to journalArticle

Yin, Xiaodong ; Xu, Jiankai ; Shi, Jinna ; Lv, Kewen ; Zhao, Eryang ; Hu, Tenglong ; Tamamura, Ryo ; Nagatsuka, Hitoshi ; Jiao, Xiaohui. / Immunohistochemical detection of erythropoietin, platelet-derived growth factor and their receptors in ameloblastomas. In: Journal of Hard Tissue Biology. 2009 ; Vol. 18, No. 1. pp. 19-26.
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