Immunohistochemical detection of carcinoembryonic antigen and P-glycoprotein in small cell lung cancer at diagnosis and relapse, with special reference to the tissue expression of CEA and response to chemotherapy

T. Ohnoshi, H. Ueoka, Y. Segawa, Katsuyuki Kiura, Masahiro Tabata, T. Shibayama, T. Maeda, M. Miyatake, N. Takigawa, I. Kimura

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Abstract

Small cell lung cancer (SCLC) is one of the most sensitive tumors to drug therapy; however, the majority of patients eventually relapse within a few years. Emergence of drug resistance is thought to play a major role in the dismal course of this disease. However, the mechanism of drug resistance in SCLC still remains obscure. Based on the clinical observation that a significant proportion of patients with relapsing tumor show an elevated serum carcinoembryonic antigen (CEA) concentration while serum neuron-specific enolase (NSE) concentration remains normal, we attempted to determine whether the tissue expression of CEA is indicative of a clonal change in SCLC, in contrast with the tissue expression of NSE and P-glycoprotein (P-gp). We examined 22 SCLC patients with tumor specimens available both at diagnosis and at relapse. Of the 22 patients, two had CEA expression at diagnosis, and a further three patients showed CEA expression at relapse. It is of note that there were two patients whose tumors expressed NSE alone at diagnosis but expressed CEA alone at relapse. Serum CEA concentration was concordant with the tissue expression of CEA; however, serum NSE concentration was not concordant with the tissue expression of NSE. Tumors with CEA expression at relapse were generally resistant to salvage chemotherapy, while there was no close relationship between the tissue expression of P-gp and refractoriness to drugs at relapse. These findings indicate that the tissue expression of CEA in SCLC is a marker of a cloncal change during chemotherapy, and such a clonal change would play a role in the emergence of drug resistance in SCLC.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalJapanese Journal of Thoracic Diseases
Volume30
Issue number2
Publication statusPublished - 1992

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Carcinoembryonic Antigen
Small Cell Lung Carcinoma
P-Glycoprotein
Phosphopyruvate Hydratase
Recurrence
Drug Therapy
Drug Resistance
Neoplasms
Serum

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Immunohistochemical detection of carcinoembryonic antigen and P-glycoprotein in small cell lung cancer at diagnosis and relapse, with special reference to the tissue expression of CEA and response to chemotherapy. / Ohnoshi, T.; Ueoka, H.; Segawa, Y.; Kiura, Katsuyuki; Tabata, Masahiro; Shibayama, T.; Maeda, T.; Miyatake, M.; Takigawa, N.; Kimura, I.

In: Japanese Journal of Thoracic Diseases, Vol. 30, No. 2, 1992, p. 262-269.

Research output: Contribution to journalArticle

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abstract = "Small cell lung cancer (SCLC) is one of the most sensitive tumors to drug therapy; however, the majority of patients eventually relapse within a few years. Emergence of drug resistance is thought to play a major role in the dismal course of this disease. However, the mechanism of drug resistance in SCLC still remains obscure. Based on the clinical observation that a significant proportion of patients with relapsing tumor show an elevated serum carcinoembryonic antigen (CEA) concentration while serum neuron-specific enolase (NSE) concentration remains normal, we attempted to determine whether the tissue expression of CEA is indicative of a clonal change in SCLC, in contrast with the tissue expression of NSE and P-glycoprotein (P-gp). We examined 22 SCLC patients with tumor specimens available both at diagnosis and at relapse. Of the 22 patients, two had CEA expression at diagnosis, and a further three patients showed CEA expression at relapse. It is of note that there were two patients whose tumors expressed NSE alone at diagnosis but expressed CEA alone at relapse. Serum CEA concentration was concordant with the tissue expression of CEA; however, serum NSE concentration was not concordant with the tissue expression of NSE. Tumors with CEA expression at relapse were generally resistant to salvage chemotherapy, while there was no close relationship between the tissue expression of P-gp and refractoriness to drugs at relapse. These findings indicate that the tissue expression of CEA in SCLC is a marker of a cloncal change during chemotherapy, and such a clonal change would play a role in the emergence of drug resistance in SCLC.",
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