Immunohistochemical demonstration of tenascin and fibronectin in odontogenic tumours and human fetal tooth germs

N. Nagai, Eiki Yamachika, K. Nishijima, M. Inoue, H. I. Shin, M. S. Suh, Hitoshi Nagatsuka

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The distribution of tenascin and fibronectin (plasma fibronectin) was studied immunohistochemically in ameloblastomas, ameloblastic fibromas and ameloblastic carcinomas, as well as in tooth germs using monoclonal antibodies. Tenascin is an extracellular matrix molecule that was shown to be enriched in the embryonic mesenchyme surrounding the budding epithelium in various organs, including the tooth. Tenascin was strongly expressed in the basement membrane zone of the ameloblastomas and in the early tooth germ and the dental lamina, but not in the dental follicle. The expression of tenascin in the ameloblastic fibroma was seen in the basement membrane of the epithelial islands throughout the stromal tissues. There were clear differences in fibronectin expression in the follicular ameloblastoma and ameloblastic carcinoma. The results suggest that tenascin and fibronectin are involved in epithelial mesenchymal interactions of the tooth germ and in odontogenic tumours.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalEuropean Journal of Cancer. Part B: Oral Oncology
Volume30
Issue number3
DOIs
Publication statusPublished - 1994

Fingerprint

Tooth Germ
Odontogenic Tumors
Tenascin
Fibronectins
Ameloblastoma
Fibroma
Basement Membrane
Tooth
Dental Sac
Carcinoma
Mesoderm
Islands
Extracellular Matrix
Epithelium
Monoclonal Antibodies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Immunohistochemical demonstration of tenascin and fibronectin in odontogenic tumours and human fetal tooth germs. / Nagai, N.; Yamachika, Eiki; Nishijima, K.; Inoue, M.; Shin, H. I.; Suh, M. S.; Nagatsuka, Hitoshi.

In: European Journal of Cancer. Part B: Oral Oncology, Vol. 30, No. 3, 1994, p. 191-195.

Research output: Contribution to journalArticle

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